دورية أكاديمية
Natural history of cervical paragangliomas: outcomes of observation of 43 patients.
| العنوان: | Natural history of cervical paragangliomas: outcomes of observation of 43 patients. |
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| المؤلفون: | Langerman A; Department of Otolaryngology,Vanderbilt Bill Wilkerson Center for Otolaryngology and Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA., Athavale SM, Rangarajan SV, Sinard RJ, Netterville JL |
| المصدر: | Archives of otolaryngology--head & neck surgery [Arch Otolaryngol Head Neck Surg] 2012 Apr; Vol. 138 (4), pp. 341-5. Date of Electronic Publication: 2012 Mar 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Medical Association Country of Publication: United States NLM ID: 8603209 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-361X (Electronic) Linking ISSN: 08864470 NLM ISO Abbreviation: Arch Otolaryngol Head Neck Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Chicago, IL] : American Medical Association, [c1986- |
| مواضيع طبية MeSH: | Head and Neck Neoplasms/*pathology , Paraganglioma, Extra-Adrenal/*pathology, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Diagnostic Imaging ; Disease Progression ; Female ; Head and Neck Neoplasms/surgery ; Humans ; Male ; Middle Aged ; Observation ; Paraganglioma, Extra-Adrenal/surgery ; Retrospective Studies ; Risk Factors |
| مستخلص: | Objective: To evaluate the outcomes, growth rate, and symptoms of nonoperated cervical paragangliomas. Design: Retrospective review of clinical and radiologic records and images. Setting: Tertiary academic medical center. Patients: We studied all patients presenting with cervical paragangliomas between 1993 and 2010 who were observed rather than operated on. Main Outcome Measures: Growth of tumors and need for surgical removal. Results: Forty-three patients with 47 tumors were identified. Mean patient age was 56 years (age range, 17-86 years). Thirty patients were asymptomatic (70%) (22 diagnosed by imaging for other reasons and 8 for workup of a neck mass), and only 5 presented with cranial nerve abnormalities (12%). No patients presented with lymphadenopathy, rapid growth, or pain. Reasons for observation were patient preference (n = 15; 35%), advanced age of patient (n = 12; 28%), and preexisting contralateral cranial nerve deficits (n = 11; 26%). Twenty-eight of the 47 tumors were suspected carotid body tumors based on imaging (60%), and 19 were suspected vagal tumors (40%). The mean greatest dimension at presentation was 2.6 cm (range, 1-7.2 cm). During a mean follow-up of 5 years (range, 1-17 years), 19 tumors remained stable in size (42%); 17 grew (38%); and 9 regressed (20%). Of the 17 tumors that grew, the mean growth was 0.2 cm/y. Conclusions: Observation of cervical paragangliomas is an option in selected patients who do not present with worrisome symptoms. The natural history of paragangliomas in these patients is typically little to no growth over time. Regular follow-up is important to ensure minimal change and stable symptoms. |
| تواريخ الأحداث: | Date Created: 20120321 Date Completed: 20120604 Latest Revision: 20120417 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1001/archoto.2012.37 |
| PMID: | 22431860 |
| قاعدة البيانات: | MEDLINE |
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