دورية أكاديمية
In vivo hydroquinone exposure impairs MCP-1 secretion and monocyte recruitment into the inflamed lung.
| العنوان: | In vivo hydroquinone exposure impairs MCP-1 secretion and monocyte recruitment into the inflamed lung. |
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| المؤلفون: | Shimada AL; Laboratory of Experimental Toxicology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Brazil., Ribeiro AL, Bolonheis SM, Ferraz-de-Paula V, Hebeda CB, Farsky SH |
| المصدر: | Toxicology [Toxicology] 2012 Jun 14; Vol. 296 (1-3), pp. 20-6. Date of Electronic Publication: 2012 Mar 23. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185 (Electronic) Linking ISSN: 0300483X NLM ISO Abbreviation: Toxicology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Original Publication: Amsterdam. Elsevier/North-Holland. |
| مواضيع طبية MeSH: | Chemokine CCL2/*metabolism , Hydroquinones/*toxicity , Immunosuppressive Agents/*toxicity , Monocytes/*drug effects , Pneumonia/*immunology, Animals ; Bronchoalveolar Lavage Fluid/cytology ; Cell Count ; Cell Line, Tumor ; Cell Movement/drug effects ; Environmental Pollutants/toxicity ; Humans ; Macrophages, Alveolar/cytology ; Male ; Mice ; Monocytes/immunology ; Pneumonia/pathology ; Smoke ; Nicotiana |
| مستخلص: | Alveolar macrophages (AMs) are important cells in the resolution of the inflammatory process and they come into direct contact with inhaled pollutants. Hydroquinone (HQ) is an environmental pollutant and a component of cigarette smoke that causes immunosuppressive effects. In the present work, we showed that mice exposed to low levels of aerosolized HQ (25 ppm; 1 h/day/5 days) presented impaired mononuclear cell migration to the lipopolysaccharide (LPS)-inflamed lung. This may have been due to reduced monocyte chemoattractant protein-1 (MCP-1) secretion into bronchoalveolar lavage fluid (BALF), and it was not related to alterations to mononuclear cell mobilization into the blood or adhesion molecules expression on mononuclear cell membranes. Corroborating the actions of HQ on MCP-1 secretion, reduced MCP-1 concentrations were also found in the supernatant of ex vivo AM and tracheal tissue collected from HQ-exposed mice. A direct action of HQ on MCP-1 secretion, resulting from impaired gene synthesis, was verified by in vitro incubation of naive AMs or tracheal tissue with HQ. The role of reduced levels of MCP-1 in the BALF on monocyte migration was analysed in the human monocytic lineage THP-1 in in vitro chemotaxis assays, which showed that the reduced concentrations of MCP-1 found in the BALF or cell supernatants from HQ-exposed mice impaired cell migration. Considering the fact that MCP-1 presents a broad spectrum of actions on pathophysiological conditions and that resident mononuclear cells are involved in lung tissue homeostasis and in immune host defence, the mechanism of HQ toxicity presented herein might be relevant to the genesis of infectious lung diseases in smokers and in inhabitants of polluted areas. (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (Chemokine CCL2) 0 (Environmental Pollutants) 0 (Hydroquinones) 0 (Immunosuppressive Agents) 0 (Smoke) XV74C1N1AE (hydroquinone) |
| تواريخ الأحداث: | Date Created: 20120403 Date Completed: 20120612 Latest Revision: 20231213 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.tox.2012.02.012 |
| PMID: | 22465845 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1879-3185 |
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| DOI: | 10.1016/j.tox.2012.02.012 |