دورية أكاديمية
Determination of furaltadone and nifursol residues in poultry eggs by liquid chromatography-electrospray ionization tandem mass spectrometry.
| العنوان: | Determination of furaltadone and nifursol residues in poultry eggs by liquid chromatography-electrospray ionization tandem mass spectrometry. |
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| المؤلفون: | Barbosa J; INRB-LNIV, Laboratório Nacional de Investigação Veterinária , Estrada de Benfica 701, 1549-011 Lisboa, Portugal., Freitas A, Mourão JL, Noronha da Silveira MI, Ramos F |
| المصدر: | Journal of agricultural and food chemistry [J Agric Food Chem] 2012 May 02; Vol. 60 (17), pp. 4227-34. Date of Electronic Publication: 2012 Apr 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Chemical Society. |
| مواضيع طبية MeSH: | Anti-Infective Agents/*analysis , Chromatography, Liquid/*methods , Eggs/*analysis , Nitrofurans/*analysis , Oxazolidinones/*analysis , Spectrometry, Mass, Electrospray Ionization/*methods, Animals ; Anti-Infective Agents/administration & dosage ; Chickens ; Diet/veterinary ; Drug Residues/analysis ; Female ; Food Contamination/analysis ; Nitrofurans/administration & dosage ; Oxazolidinones/administration & dosage ; Reproducibility of Results ; Tandem Mass Spectrometry/methods ; Veterinary Drugs/analysis |
| مستخلص: | The use of nitrofurans as veterinary drugs has been banned from intensive animal production in the European Union (EU) since 1993. The objective of the present study was to evaluate the accumulation and depletion of furaltadone and nifursol and their side-chain metabolites 5-methylmorpholino-3-amino-2-oxazolidinone (AMOZ) and 3,5-dinitrosalicylic acid hydrazide (DNSAH) in eggs after administration of therapeutic and subtherapeutic doses of the drugs to laying hens during three consecutive weeks. LC-MS/MS, with positive and negative electrospray ionization methods, was used for the determination of parent compounds and metabolites in yolk and egg white and was validated according to criteria established by Commission Decision 2002/657/EC. The decision limit (CCα) and the detection capability (CCβ) of the analytical methodology for metabolites were 0.1 and 0.5 μg/kg for AMOZ and 0.3 and 0.9 μg/kg for DNSAH, respectively. For the parent compounds, CCα and CCβ were 0.9 and 2.0 μg/kg for furaltadone and 1.3 and 3.1 μg/kg for nifursol, respectively. The data obtained show that the parent compounds are much less persistent than their side-chain metabolites in either yolk or egg white. Between the studied metabolites, AMOZ is the most persistent and could be detected in either yolk or egg white three weeks following withdrawal from treatment. |
| المشرفين على المادة: | 0 (Anti-Infective Agents) 0 (Nitrofurans) 0 (Oxazolidinones) 0 (Veterinary Drugs) 5X4V82ZN30 (furaltadon) TG99GOU55Z (nifursol) |
| تواريخ الأحداث: | Date Created: 20120411 Date Completed: 20120817 Latest Revision: 20141120 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1021/jf205186y |
| PMID: | 22486660 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5118 |
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| DOI: | 10.1021/jf205186y |