دورية أكاديمية
Soluble BAFF-R produced by decidual stromal cells plays an inhibitory role in monocytes and macrophages.
| العنوان: | Soluble BAFF-R produced by decidual stromal cells plays an inhibitory role in monocytes and macrophages. |
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| المؤلفون: | Deng BP; Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, PR China., Zhang Y, Wang QJ, Xu XF, Zhang H, Yang YM, Mao HT, Gao WJ, Song BF, Kong BH, Qu X |
| المصدر: | Reproductive biomedicine online [Reprod Biomed Online] 2012 Jun; Vol. 24 (6), pp. 654-63. Date of Electronic Publication: 2012 Mar 09. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101122473 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-6491 (Electronic) Linking ISSN: 14726483 NLM ISO Abbreviation: Reprod Biomed Online Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2009->: Amsterdam : Elsevier Original Publication: Cambridge, UK : Reproductive Healthcare Ltd. |
| مواضيع طبية MeSH: | B-Cell Activation Factor Receptor/*metabolism , B-Cell Activation Factor Receptor/*pharmacology , Decidua/*metabolism , Macrophages/*drug effects , Monocytes/*drug effects, Cell Proliferation/drug effects ; Cells, Cultured ; Decidua/cytology ; Decidua/drug effects ; Female ; Humans ; In Vitro Techniques ; Interleukin-6/metabolism ; Macrophages/cytology ; Macrophages/metabolism ; Monocytes/cytology ; Monocytes/metabolism ; Poly I-C/metabolism ; Poly I-C/pharmacology ; Pregnancy ; Pregnancy Trimester, First ; Stromal Cells/cytology ; Stromal Cells/drug effects ; Stromal Cells/metabolism ; Toll-Like Receptor 3/metabolism ; Tumor Necrosis Factor-alpha/metabolism |
| مستخلص: | A sophisticated immunological regulation between decidual stromal cells (DSC) and monocytes and macrophages is essential for the successful symbiosis of the mother and her fetus, but the mechanisms remain incompletely understood. The mRNA and proteins of B lymphocyte stimulator (BAFF, also known as BLys) and its receptor, BAFF-R (also known as BR3, CD268 or TNFRSF17), have been detected in both first-trimester and term placentas, but whether BAFF or BAFF-R participates in the cross-talk between DSC and monocytes and macrophages in the first-trimester pregnancy has not been described. This study found that purified DSC extensively shed BAFF-R and that polyinosinic:polycytidylic acid (poly(I:C); a synthetic toll-like receptor (TLR) 3 agonist) dramatically up-regulated BAFF-R secretion, suggesting that release of these soluble proteins was an inherent property of DSC and its induction might have relevance to TLR-3-mediated signal transduction. When monocytes were cultured with the supernatants of resting DSC or poly(I:C)-treated DSC, the proliferation of CD14(+)HLA-DR(+) monocytes (P=0.025 and 0.045) and the secretion levels of tumour necrosis factor α (P=0.035 and 0.031) and interleukin 6 (P=0.021 and 0.035) were significantly increased after the BAFF-R was blocked. Soluble BAFF-R may play inhibitory roles in monocytes and macrophages. (Copyright © 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (B-Cell Activation Factor Receptor) 0 (Interleukin-6) 0 (TLR3 protein, human) 0 (TNFRSF13C protein, human) 0 (Toll-Like Receptor 3) 0 (Tumor Necrosis Factor-alpha) O84C90HH2L (Poly I-C) |
| تواريخ الأحداث: | Date Created: 20120417 Date Completed: 20121101 Latest Revision: 20220408 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.rbmo.2012.02.024 |
| PMID: | 22503273 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1472-6491 |
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| DOI: | 10.1016/j.rbmo.2012.02.024 |