دورية أكاديمية
أعرض في EDS

Jagged1 and Notch1 help edit M cell patterning in Peyer's patch follicle epithelium.

التفاصيل البيبلوغرافية
العنوان: Jagged1 and Notch1 help edit M cell patterning in Peyer's patch follicle epithelium.
المؤلفون: Hsieh EH; Division of Biomedical Sciences, University of California Riverside, CA 92521, United States., Lo DD
المصدر: Developmental and comparative immunology [Dev Comp Immunol] 2012 Jun; Vol. 37 (2), pp. 306-12. Date of Electronic Publication: 2012 Apr 12.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7708205 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0089 (Electronic) Linking ISSN: 0145305X NLM ISO Abbreviation: Dev Comp Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: Tarrytown Ny : Elsevier Science
Original Publication: Elmsford, N. Y., Pergamon Press., 1977-2004.
مواضيع طبية MeSH: Calcium-Binding Proteins/*metabolism , Intercellular Signaling Peptides and Proteins/*metabolism , Intestinal Mucosa/*cytology , Intestinal Mucosa/*immunology , Membrane Proteins/*metabolism , Peyer's Patches/*cytology , Peyer's Patches/*immunology , Receptor, Notch1/*metabolism, Animals ; Goblet Cells/immunology ; Intestinal Mucosa/metabolism ; Jagged-1 Protein ; Mice ; Monitoring, Immunologic ; Peyer's Patches/metabolism ; Serrate-Jagged Proteins
مستخلص: Mucosal epithelium M cells are dispersed across Peyer's patch follicle associated epithelium (PPFAE) with minimal clustering. Since Notch signaling can influence patterning in epithelia, we examined its influence on PPFAE M cell distribution. Conditional deletion of Notch1 in intestinal epithelium increased PPFAE M cells and also increased M cell clustering, implying a role for Notch in both M cell numbers and lateral inhibition. By contrast, conditional deletion of the ligand Jagged1 also increased M cell clustering, but with a paradoxical decrease in M cell density. In vitro, inhibition of Notch signaling reduced expression of an M cell associated gene CD137, consistent with cis-promoting effects on M cell development. Thus, Jagged1 may have a cis-promoting role in committed M cells, but a trans-inhibitory effect on neighboring cells. In sum, Jagged1-Notch signaling may edit the pattern of M cells across the PPFAE, which may help optimize mucosal immune surveillance.
(Copyright © 2012 Elsevier Ltd. All rights reserved.)
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معلومات مُعتمدة: R01 AI063426 United States AI NIAID NIH HHS; R21 AI073689 United States AI NIAID NIH HHS; R56 AI063426 United States AI NIAID NIH HHS; R21 AI073689 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Calcium-Binding Proteins)
0 (Intercellular Signaling Peptides and Proteins)
0 (Jag1 protein, mouse)
0 (Jagged-1 Protein)
0 (Membrane Proteins)
0 (Notch1 protein, mouse)
0 (Receptor, Notch1)
0 (Serrate-Jagged Proteins)
تواريخ الأحداث: Date Created: 20120417 Date Completed: 20120831 Latest Revision: 20211021
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3374009
DOI: 10.1016/j.dci.2012.04.003
PMID: 22504165
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0089
DOI:10.1016/j.dci.2012.04.003