دورية أكاديمية
High novelty-seeking predicts greater sensitivity to the conditioned rewarding effects of cocaine.
| العنوان: | High novelty-seeking predicts greater sensitivity to the conditioned rewarding effects of cocaine. |
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| المؤلفون: | Vidal-Infer A; Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de València, Valencia, 46010, Spain., Arenas MC, Daza-Losada M, Aguilar MA, Miñarro J, Rodríguez-Arias M |
| المصدر: | Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2012 Jul; Vol. 102 (1), pp. 124-32. Date of Electronic Publication: 2012 Apr 06. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0367050 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5177 (Electronic) Linking ISSN: 00913057 NLM ISO Abbreviation: Pharmacol Biochem Behav Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tarrytown, NY : Elsevier Original Publication: Phoenix, N. Y. Ankho International, ltd. |
| مواضيع طبية MeSH: | Reward*, Cocaine/*pharmacology , Conditioning, Psychological/*drug effects , Exploratory Behavior/*drug effects, Animals ; Conditioning, Psychological/physiology ; Exploratory Behavior/physiology ; Female ; Male ; Mice ; Predictive Value of Tests ; Reaction Time/drug effects ; Reaction Time/physiology |
| مستخلص: | Novelty-seeking in rodents, defined as enhanced specific exploration of novel situations, is considered to predict the response of animals to drugs of abuse and, thus, identify "drug-vulnerable" individuals. The main objective of this work was to determine the capacity of two animal models-the novel object recognition task and the novel environment test-for evaluating to what extent novelty-seeking can predict greater sensitivity to the rewarding properties of cocaine in young adult (PND 56) and adolescent (PND 35) OF1 mice of both sexes. Conditioned place preference, a useful tool for evaluating the sensitivity of individuals to the incentive properties of addictive drugs, was induced with a sub-threshold dose of cocaine (1 mg/kg, i.p.). Three factors that predispose individuals to addiction were considered: age, sex and novelty-seeking trait. CPP was detected only in the young adults that spent most time exploring the novel environment (High Novel Environment Seekers, High-Environment-NS). The novel environment test seemed to be more effective than the novel object recognition task in identifying young adults vulnerable to drugs; specifically, it revealed a distinction between High- and Low-Environment-NS mice that predicted greater sensitivity to the rewarding properties of cocaine among young adults but not among adolescents. Although our results reveal a higher novelty preference among young adult females than among their male counterparts in the two NS tests, both sexes showed similar susceptibility to the rewarding effects of a sub-threshold dose of cocaine in the CPP. These findings suggest that screening can identify humans at-risk of becoming drug users, and may contribute to the development of prevention strategies based on specific vulnerabilities. (Copyright © 2012 Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | I5Y540LHVR (Cocaine) |
| تواريخ الأحداث: | Date Created: 20120418 Date Completed: 20130314 Latest Revision: 20191210 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.pbb.2012.03.031 |
| PMID: | 22507913 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-5177 |
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| DOI: | 10.1016/j.pbb.2012.03.031 |