دورية أكاديمية
Antioxidants for preventing preeclampsia: a systematic review.
| العنوان: | Antioxidants for preventing preeclampsia: a systematic review. |
|---|---|
| المؤلفون: | Salles AM; University of Brasilia, Faculty of Medicine, Asa Norte, 70910-900 Brasilia, DF, Brazil., Galvao TF, Silva MT, Motta LC, Pereira MG |
| المصدر: | TheScientificWorldJournal [ScientificWorldJournal] 2012; Vol. 2012, pp. 243476. Date of Electronic Publication: 2012 Apr 19. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hindawi Publishing Corporation Country of Publication: United States NLM ID: 101131163 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-744X (Electronic) Linking ISSN: 1537744X NLM ISO Abbreviation: ScientificWorldJournal Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Hindawi Publishing Corporation Original Publication: Boynton Beach, FL : Scientific World, Inc., c2001- |
| مواضيع طبية MeSH: | Antioxidants/*therapeutic use , Pre-Eclampsia/*prevention & control, Antioxidants/adverse effects ; Female ; Humans ; Infant, Newborn ; Infant, Premature ; Pre-Eclampsia/pathology ; Pregnancy ; Pregnancy Outcome ; Randomized Controlled Trials as Topic ; Treatment Outcome |
| مستخلص: | Objective: To investigate the efficacy of antioxidants for preventing preeclampsia and other maternal and fetal complications among pregnant women with low, moderate, or high risk of preeclampsia. Methods: We searched MEDLINE, Embase, CENTRAL, mRCT, and other databases, with no language or publication restrictions. Two independent reviewers selected randomized controlled trials that evaluated the use of antioxidants versus placebo and extracted the relevant data. Relative risks (RRs) and 95% confidence intervals (95% CIs) were calculated. The data were compiled through the random effects model. Main Results: Fifteen studies were included (21,012 women and 21,647 fetuses). No statistically significant difference was found between women who received antioxidant treatment and women who received placebo for preeclampsia (RR = 0.92; 95% CI: 0.82-1.04), severe preeclampsia (RR = 1.03; 95% CI: 0.87-1.22), preterm birth (RR = 1.03; 95% CI: 0.94-1.14), and small for gestational age <10th centile (RR = 0.92; 95% CI: 0.80-1.05). Side effects were numerically more frequent in the antioxidants group compared to placebo, but without significant statistical difference (RR = 1.24; 95% CI: 0.85-1.80). Conclusions: The available evidence reviewed does not support the use of antioxidants during pregnancy for the prevention of preeclampsia and other outcomes. |
| References: | Diabetes Educ. 2009 Nov-Dec;35(6):1004-13. (PMID: 19696205) Int J Gynaecol Obstet. 2003 Jun;81(3):257-62. (PMID: 12767566) N Engl J Med. 2006 Apr 27;354(17):1796-806. (PMID: 16641396) Obstet Gynecol Surv. 2010 Oct;65(10):653-67. (PMID: 21182804) Chin Med J (Engl). 1994 Nov;107(11):870-1. (PMID: 7867399) BJOG. 2009 May;116(6):780-8. (PMID: 19432566) Lancet. 2010 Jul 24;376(9737):259-66. (PMID: 20580423) Stat Med. 2006 Oct 30;25(20):3443-57. (PMID: 16345038) J Obstet Gynaecol Res. 2009 Jun;35(3):438-45. (PMID: 19527380) BMJ. 2011 May 19;342:d2901. (PMID: 21596735) Hypertension. 1999 Jan;33(1):83-9. (PMID: 9931086) Am J Obstet Gynecol. 2005 Feb;192(2):520-1. (PMID: 15695996) Int J Gynaecol Obstet. 2009 Apr;105(1):43-5. (PMID: 19154996) JAMA. 2006 Feb 8;295(6):676-80. (PMID: 16467236) Arch Gynecol Obstet. 2003 Feb;267(4):189-95. (PMID: 12592416) Am J Obstet Gynecol. 2010 Mar;202(3):239.e1-239.e10. (PMID: 20207239) Obstet Gynecol. 2007 Dec;110(6):1311-8. (PMID: 18055726) Lancet. 1999 Sep 4;354(9181):810-6. (PMID: 10485722) Lancet. 2006 Apr 8;367(9517):1145-54. (PMID: 16616557) J Obstet Gynaecol Res. 2009 Jun;35(3):477-82. (PMID: 19527386) Am J Clin Nutr. 2005 Apr;81(4):859-63. (PMID: 15817864) Cochrane Database Syst Rev. 2005 Apr 18;(2):CD004069. (PMID: 15846695) Int J Gynaecol Obstet. 2008 Mar;100(3):252-6. (PMID: 18005966) Cochrane Database Syst Rev. 2008 Jan 23;(1):CD004227. (PMID: 18254042) Hypertension. 2004 Oct;44(4):374-80. (PMID: 15326082) Taiwan J Obstet Gynecol. 2010 Jun;49(2):181-7. (PMID: 20708525) Obstet Gynecol Surv. 2007 Mar;62(3):202-6. (PMID: 17306042) J Obstet Gynaecol. 2003 Mar;23(2):150-5. (PMID: 12745558) N Engl J Med. 2010 Apr 8;362(14):1282-91. (PMID: 20375405) Am J Obstet Gynecol. 2011 Jun;204(6):503.e1-12. (PMID: 21529757) Hypertens Pregnancy. 2006;25(3):241-53. (PMID: 17065044) BMC Pregnancy Childbirth. 2008 Jul 30;8:31. (PMID: 18664297) Lancet. 2006 Apr 1;367(9516):1066-1074. (PMID: 16581405) J Nutr. 2005 Jul;135(7):1776-81. (PMID: 15987864) Eur J Obstet Gynecol Reprod Biol. 2011 Sep;158(1):9-16. (PMID: 21641104) |
| المشرفين على المادة: | 0 (Antioxidants) |
| تواريخ الأحداث: | Date Created: 20120518 Date Completed: 20121009 Latest Revision: 20240529 |
| رمز التحديث: | 20240529 |
| مُعرف محوري في PubMed: | PMC3349130 |
| DOI: | 10.1100/2012/243476 |
| PMID: | 22593668 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-744X |
|---|---|
| DOI: | 10.1100/2012/243476 |