دورية أكاديمية
أعرض في EDS

Early warning indicators for HIV drug resistance in Cameroon during the year 2010.

التفاصيل البيبلوغرافية
العنوان: Early warning indicators for HIV drug resistance in Cameroon during the year 2010.
المؤلفون: Billong SC; National HIV Drug Resistance Surveillance and Prevention Working Group, HIVDR-WG, National AIDS Control Committee, Yaounde, Cameroon. sergebillong@yahoo.fr, Fokam J, Nkwescheu AS, Kembou E, Milenge P, Tsomo Z, Dion GN, Aghokeng AF, Mpoudi EN, Ndumbe PM, Colizzi V, Elat Nfetam JB
المصدر: PloS one [PLoS One] 2012; Vol. 7 (5), pp. e36777. Date of Electronic Publication: 2012 May 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Drug Resistance, Viral*, HIV/*drug effects, Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use ; Cameroon ; HIV Infections/drug therapy ; Humans
مستخلص: Background: Rapid scale-up of antiretroviral therapy (ART) in resource-limited settings is accompanied with an increasing risk of HIV drug resistance (HIVDR), which in turn could compromise the performance of national ART rollout programme. In order to sustain the effectiveness of ART in a resource-limited country like Cameroon, HIVDR early warning indicators (EWI) may provide relevant corrective measures to support the control and therapeutic management of AIDS.
Methods: A retrospective study was conducted in 2010 among 40 ART sites (12 Approved Treatment Centers and 28 Management Units) distributed over the 10 regions of Cameroon. Five standardized EWIs were selected for the evaluation using data from January through December, among which: (1) Good ARV prescribing practices: target = 100%; (2) Patient lost to follow-up: target ≤ 20%; (3) Patient retention on first line ART: target ≥ 70%; (4) On-time drug pick-up: target ≥ 90%; (5) ARV drug supply continuity: target = 100%. Analysis was performed using a Data Quality Assessment tool, following WHO protocol.
Results: THE NUMBER OF SITES ATTAINING THE REQUIRED PERFORMANCE ARE: 90% (36/40) for EWI(1), 20% (8/40) for EWI(2); 20% (8/40) for EWI(3); 0% (0/37) for EWI(4); and 45% (17/38) for EWI 5. ARV prescribing practices were in conformity with the national guidelines in almost all the sites, whereas patient adherence to ART (EWI(2), EWI(3), and EWI(4)) was very low. A high rate of patients was lost-to-follow-up and others failing first line ART before 12 months of initiation. Discontinuity in drug supply observed in about half of the sites may negatively impact ARV prescription and patient adherence. These poor ART performances may also be due to low number of trained staff and community disengagement.
Conclusions: The poor performance of the national ART programme, due to patient non-adherence and drug stock outs, requires corrective measures to limit risks of HIVDR emergence in Cameroon.
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المشرفين على المادة: 0 (Anti-HIV Agents)
تواريخ الأحداث: Date Created: 20120523 Date Completed: 20120914 Latest Revision: 20220317
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC3355154
DOI: 10.1371/journal.pone.0036777
PMID: 22615810
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0036777