دورية أكاديمية
أعرض في EDS

Common pathways for receptor-mediated ingestion of Escherichia coli and LDL cholesterol by Entamoeba histolytica regulated in part by transmembrane kinase 39.

التفاصيل البيبلوغرافية
العنوان: Common pathways for receptor-mediated ingestion of Escherichia coli and LDL cholesterol by Entamoeba histolytica regulated in part by transmembrane kinase 39.
المؤلفون: Christy NC; Department of Microbiology, Immunology and Cancer Biology, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA., Buss SN, Petri WA Jr
المصدر: International journal for parasitology [Int J Parasitol] 2012 Apr; Vol. 42 (4), pp. 393-400.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0314024 Publication Model: Print Cited Medium: Internet ISSN: 1879-0135 (Electronic) Linking ISSN: 00207519 NLM ISO Abbreviation: Int J Parasitol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Elsevier Science
Original Publication: Oxford, New York, Pergamon Press.
مواضيع طبية MeSH: Phagocytosis* , Protein Transport*, Cholesterol, LDL/*metabolism , Entamoeba histolytica/*enzymology , Entamoeba histolytica/*physiology , Escherichia coli/*isolation & purification , Phosphotransferases/*metabolism, Entamoeba histolytica/metabolism ; Entamoeba histolytica/microbiology ; Erythrocytes/metabolism ; Erythrocytes/microbiology ; Humans ; Jurkat Cells/metabolism ; Jurkat Cells/microbiology
مستخلص: The single-celled parasite, Entamoeba histolytica, is an enteric pathogen that ingests bacteria and host cells. Inhibition of phagocytosis renders the parasite avirulent. The ligand/receptor interactions that allow E. histolytica to phagocytose are not well understood. We hypothesised that E. histolytica trophozoites might accomplish ingestion through the utilisation of a scavenger receptor for cholesterol. Here we show that acetylated low density lipoprotein cholesterol was phagocytosed by amoebae via receptor mediated mechanisms. Acetylated low density lipoprotein cholesterol competitively inhibited by 31 ± 1.3% (P < 0.005) the ingestion of Escherichia coli, but not erythrocytes and Jurkat T lymphocytes, suggesting a partially redundant phagocytic pathway for E. coli and cholesterol. Inducible expression ofa signalling-dead dominant-negative version of E. histolytica transmembrane kinase 39 inhibited ingestion of E. coli by 55 ± 3% (P < 0.005) but not LDL particles. We concluded that ingestion of E. coli was regulated by TMK39 and partially shared the acetylated low density lipoprotein cholesterol uptake pathway.
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معلومات مُعتمدة: R01 AI026649-22 United States AI NIAID NIH HHS; R37 AI026649 United States AI NIAID NIH HHS; AI26649 United States AI NIAID NIH HHS; T32 AI007046 United States AI NIAID NIH HHS; R01 AI026649 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Cholesterol, LDL)
EC 2.7.- (Phosphotransferases)
تواريخ الأحداث: Date Created: 20120524 Date Completed: 20120803 Latest Revision: 20211021
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3449034
DOI: 10.1016/j.ijpara.2012.02.009
PMID: 22619755
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0135
DOI:10.1016/j.ijpara.2012.02.009