دورية أكاديمية
[Activity of lactate dehydrogenase in the brain cortex and hippocampus of Mongolian gerbils after global ischemia and reperfusion injuries].
| العنوان: | [Activity of lactate dehydrogenase in the brain cortex and hippocampus of Mongolian gerbils after global ischemia and reperfusion injuries]. |
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| المؤلفون: | Shcherbak NS, Galagudza MM, Ovchinnikov DA, Kuz'menkov AN, Iukina GIu, Barantsevich ER, Tomson VV, Shliakhto EV |
| المصدر: | Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova [Ross Fiziol Zh Im I M Sechenova] 2012 Feb; Vol. 98 (2), pp. 186-93. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Nauka Country of Publication: Russia (Federation) NLM ID: 9715665 Publication Model: Print Cited Medium: Print ISSN: 0869-8139 (Print) Linking ISSN: 08698139 NLM ISO Abbreviation: Ross Fiziol Zh Im I M Sechenova Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: S.-Peterburg : Nauka Original Publication: Sankt-Peterburg : "Nauka", c1997- |
| مواضيع طبية MeSH: | Cerebral Cortex/*metabolism , Hippocampus/*metabolism , L-Lactate Dehydrogenase/*metabolism , Reperfusion Injury/*metabolism, Animals ; Cytoplasm/metabolism ; Gerbillinae/metabolism ; Pyramidal Cells/metabolism |
| مستخلص: | Cerebral ischemia results in severe derangements of energy metabolism in the nervous tissue including activation of glycolytic pathway. Activity of cytosolic lactate dehydrogenase (LDH) in the specific brain structures remains unclear. The recent study was aimed at investigation into the LDH activity in the cytoplasm of both hippocampal and cortical neurons in Mongolian gerbils (Meriones unguiculatus) at different durations of reperfusion after global ischemia. Analysis showed that the activity of LDH in pyramidal neurons of various hippocampal areas and neurons of II, III and V cortical layers after 7-minute forebrain ischemia depended on both localization of the neurons and duration ofreperfusion. In general, the changes in postischemic cytosolic LDH activity include significant decrease in the LDH activity 2 days after reperfusion with varying degree of recovery on day 7 of reperfusion. |
| المشرفين على المادة: | EC 1.1.1.27 (L-Lactate Dehydrogenase) |
| تواريخ الأحداث: | Date Created: 20120602 Date Completed: 20120731 Latest Revision: 20161020 |
| رمز التحديث: | 20231215 |
| PMID: | 22650061 |
| قاعدة البيانات: | MEDLINE |
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