دورية أكاديمية
أعرض في EDS

Modulation of iron metabolism in aging and in Alzheimer's disease: relevance of the choroid plexus.

التفاصيل البيبلوغرافية
العنوان: Modulation of iron metabolism in aging and in Alzheimer's disease: relevance of the choroid plexus.
المؤلفون: Mesquita SD; School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho Braga, Portugal., Ferreira AC, Sousa JC, Santos NC, Correia-Neves M, Sousa N, Palha JA, Marques F
المصدر: Frontiers in cellular neuroscience [Front Cell Neurosci] 2012 May 22; Vol. 6, pp. 25. Date of Electronic Publication: 2012 May 22 (Print Publication: 2012).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477935 Publication Model: eCollection Cited Medium: Internet ISSN: 1662-5102 (Electronic) Linking ISSN: 16625102 NLM ISO Abbreviation: Front Cell Neurosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Research Foundation, 2007-
مستخلص: Iron is essential for mammalian cellular homeostasis. However, in excess, it promotes free radical formation and is associated with aging-related progressive deterioration and with neurodegenerative disorders such as Alzheimer's disease (AD). There are no mechanisms to excrete iron, which makes iron homeostasis a very tightly regulated process at the level of the intestinal absorption. Iron is believed to reach the brain through receptor-mediated endocytosis of iron-bound transferrin by the brain barriers, the blood-cerebrospinal fluid (CSF) barrier, formed by the choroid plexus (CP) epithelial cells and the blood-brain barrier (BBB) formed by the endothelial cells of the brain capillaries. Importantly, the CP epithelial cells are responsible for producing most of the CSF, the fluid that fills the brain ventricles and the subarachnoid space. Recently, the finding that the CP epithelial cells display all the machinery to locally control iron delivery into the CSF may suggest that the general and progressive senescence of the CP may be at the basis of the impairment of regional iron metabolism, iron-mediated toxicity, and the increase in inflammation and oxidative stress that occurs with aging and, particularly, in AD.
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فهرسة مساهمة: Keywords: Alzheimer's disease; aging; cerebrospinal fluid; choroid plexus; iron
تواريخ الأحداث: Date Created: 20120605 Date Completed: 20121002 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3357636
DOI: 10.3389/fncel.2012.00025
PMID: 22661928
قاعدة البيانات: MEDLINE
الوصف
تدمد:1662-5102
DOI:10.3389/fncel.2012.00025