دورية أكاديمية
Prognostic role of indoleamine 2,3-dioxygenase in endometrial carcinoma.
| العنوان: | Prognostic role of indoleamine 2,3-dioxygenase in endometrial carcinoma. |
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| المؤلفون: | de Jong RA; University of Groningen, University Medical Center Groningen, Department of Gynecologic Oncology, P.O. Box 30.001, 9700 RB Groningen, The Netherlands., Kema IP, Boerma A, Boezen HM, van der Want JJ, Gooden MJ, Hollema H, Nijman HW |
| المصدر: | Gynecologic oncology [Gynecol Oncol] 2012 Sep; Vol. 126 (3), pp. 474-80. Date of Electronic Publication: 2012 Jun 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 0365304 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-6859 (Electronic) Linking ISSN: 00908258 NLM ISO Abbreviation: Gynecol Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, Academic Press. |
| مواضيع طبية MeSH: | T-Lymphocytes*, Carcinoma/*enzymology , Carcinoma/*immunology , Endometrial Neoplasms/*enzymology , Endometrial Neoplasms/*immunology , Indoleamine-Pyrrole 2,3,-Dioxygenase/*metabolism, Aged ; CD8-Positive T-Lymphocytes ; Carcinoma/pathology ; Cell Line, Tumor ; Confidence Intervals ; Disease-Free Survival ; Endometrial Neoplasms/pathology ; Female ; Forkhead Transcription Factors ; Humans ; Lymphocyte Count ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness ; Odds Ratio ; Proportional Hazards Models |
| مستخلص: | Objective: Indoleamine-2,3-dioxygenase (IDO) suppresses the function of T-lymphocytes and is an important immune escape mechanism for cancer. Therefore, it is to be expected that IDO influences prognosis of cancer patients. This study aimed to investigate the prognostic role of IDO expression in a large cohort of endometrial carcinoma (EC) patients. Methods: A tissue microarray containing primary EC tissue of 355 patients treated in a single institution was used to evaluate IDO expression. Expression of IDO was associated with clinicopathological characteristics, survival and previously determined numbers of CD8(+) and Foxp3(+) T-lymphocytes. Results: IDO(high) expression was associated with lower numbers of intratumoral CD8(+) T-lymphocytes (p=0.031). Next to well-known prognostic parameters, IDO(high) expression was independently associated with poor disease specific survival in the general cohort of EC patients (HR 2.62, 95% C.I. 1.48-4.66, p=0.001) and among patients with early stage EC (HR 3.06, 95% C.I. 1.10-8.54, p=0.032). Conclusion: Our results show that IDO expression is associated with poor survival. This provides evidence that further research into the use of IDO blocking agents in cancer treatment is valid where it might be a promising new therapeutic strategy. (Copyright © 2012 Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 0 (FOXP3 protein, human) 0 (Forkhead Transcription Factors) 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase) |
| تواريخ الأحداث: | Date Created: 20120607 Date Completed: 20121016 Latest Revision: 20201215 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.ygyno.2012.05.034 |
| PMID: | 22668882 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1095-6859 |
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| DOI: | 10.1016/j.ygyno.2012.05.034 |