دورية أكاديمية
Serological evidence of Ebola virus infection in Indonesian orangutans.
| العنوان: | Serological evidence of Ebola virus infection in Indonesian orangutans. |
|---|---|
| المؤلفون: | Nidom CA; Avian Influenza-zoonosis Research Center, Airlangga University, Surabaya, Indonesia. nidomca@unair.ac.id, Nakayama E, Nidom RV, Alamudi MY, Daulay S, Dharmayanti IN, Dachlan YP, Amin M, Igarashi M, Miyamoto H, Yoshida R, Takada A |
| المصدر: | PloS one [PLoS One] 2012; Vol. 7 (7), pp. e40740. Date of Electronic Publication: 2012 Jul 18. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
| مواضيع طبية MeSH: | Ape Diseases/*blood , Ape Diseases/*virology , Ebolavirus/*physiology , Hemorrhagic Fever, Ebola/*veterinary , Pongo/*blood , Pongo/*virology, Animals ; Antibodies, Viral/blood ; Ape Diseases/epidemiology ; Ape Diseases/immunology ; Ebolavirus/immunology ; Female ; Hemorrhagic Fever, Ebola/blood ; Hemorrhagic Fever, Ebola/immunology ; Hemorrhagic Fever, Ebola/virology ; Humans ; Immunoglobulin G/blood ; Indonesia/epidemiology ; Male ; Seroepidemiologic Studies ; Species Specificity |
| مستخلص: | Ebola virus (EBOV) and Marburg virus (MARV) belong to the family Filoviridae and cause severe hemorrhagic fever in humans and nonhuman primates. Despite the discovery of EBOV (Reston virus) in nonhuman primates and domestic pigs in the Philippines and the serological evidence for its infection of humans and fruit bats, information on the reservoirs and potential amplifying hosts for filoviruses in Asia is lacking. In this study, serum samples collected from 353 healthy Bornean orangutans (Pongo pygmaeus) in Kalimantan Island, Indonesia, during the period from December 2005 to December 2006 were screened for filovirus-specific IgG antibodies using a highly sensitive enzyme-linked immunosorbent assay (ELISA) with recombinant viral surface glycoprotein (GP) antigens derived from multiple species of filoviruses (5 EBOV and 1 MARV species). Here we show that 18.4% (65/353) and 1.7% (6/353) of the samples were seropositive for EBOV and MARV, respectively, with little cross-reactivity among EBOV and MARV antigens. In these positive samples, IgG antibodies to viral internal proteins were also detected by immunoblotting. Interestingly, while the specificity for Reston virus, which has been recognized as an Asian filovirus, was the highest in only 1.4% (5/353) of the serum samples, the majority of EBOV-positive sera showed specificity to Zaire, Sudan, Cote d'Ivoire, or Bundibugyo viruses, all of which have been found so far only in Africa. These results suggest the existence of multiple species of filoviruses or unknown filovirus-related viruses in Indonesia, some of which are serologically similar to African EBOVs, and transmission of the viruses from yet unidentified reservoir hosts into the orangutan populations. Our findings point to the need for risk assessment and continued surveillance of filovirus infection of human and nonhuman primates, as well as wild and domestic animals, in Asia. |
| التعليقات: | Expression of concern in: PLoS One. 2013;8(3):e60289. (PMID: 23527312) |
| References: | Virus Res. 2005 Aug;111(2):132-47. (PMID: 15893837) BMC Infect Dis. 2009 Sep 28;9:159. (PMID: 19785757) Science. 2004 Jan 16;303(5656):387-90. (PMID: 14726594) Nature. 2005 Dec 1;438(7068):575-6. (PMID: 16319873) PLoS Negl Trop Dis. 2011 Jun;5(6):e1175. (PMID: 21666792) J Virol. 2004 Jul;78(14):7344-51. (PMID: 15220407) Virology. 2000 Nov 10;277(1):147-55. (PMID: 11062045) PLoS Pathog. 2009 Jul;5(7):e1000536. (PMID: 19649327) Rev Med Virol. 2006 May-Jun;16(3):151-65. (PMID: 16710839) Emerg Infect Dis. 2011 Aug;17(8):1559-60. (PMID: 21801651) Rev Med Virol. 2008 Sep-Oct;18(5):331-46. (PMID: 18615782) Mol Cell Biol. 1987 Jan;7(1):379-87. (PMID: 3031469) PLoS Pathog. 2011 Oct;7(10):e1002304. (PMID: 22039362) J Virol. 2003 Jan;77(2):1069-74. (PMID: 12502822) Clin Vaccine Immunol. 2010 Nov;17(11):1723-8. (PMID: 20861331) PLoS Pathog. 2008 Nov;4(11):e1000212. (PMID: 19023410) Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9345-50. (PMID: 10430945) Mol Phylogenet Evol. 2004 May;31(2):431-9. (PMID: 15062785) J Infect Dis. 1999 Feb;179 Suppl 1:S127-38. (PMID: 9988176) Science. 2009 Jul 10;325(5937):204-6. (PMID: 19590002) Trends Microbiol. 2004 Oct;12(10):433-7. (PMID: 15381189) PLoS Pathog. 2006 Jul;2(7):e73. (PMID: 16848640) Curr Top Microbiol Immunol. 1999;235:117-43. (PMID: 9893382) Trends Microbiol. 2008 Feb;16(2):80-8. (PMID: 18191569) J Virol. 2007 May;81(9):4895-9. (PMID: 17301151) Trends Microbiol. 2007 Sep;15(9):408-16. (PMID: 17698361) J Infect Dis. 2011 Nov;204 Suppl 3:S978-85. (PMID: 21987779) |
| المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Immunoglobulin G) |
| تواريخ الأحداث: | Date Created: 20120721 Date Completed: 20130321 Latest Revision: 20240318 |
| رمز التحديث: | 20240318 |
| مُعرف محوري في PubMed: | PMC3399888 |
| DOI: | 10.1371/journal.pone.0040740 |
| PMID: | 22815803 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!