دورية أكاديمية
[The influence of N-stearoylethanolamine on the activity of antioxidant enzymes and on the level of stable NO metabolites in the rat testes and blood plasma at the early stages of streptozotocine-induced diabetes].
| العنوان: | [The influence of N-stearoylethanolamine on the activity of antioxidant enzymes and on the level of stable NO metabolites in the rat testes and blood plasma at the early stages of streptozotocine-induced diabetes]. |
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| المؤلفون: | Gorid'ko TM, Kosiakova HV, Berdyshev AH, Bazylians'ka VR, Margitych VM, Gula NM |
| المصدر: | Ukrains'kyi biokhimichnyi zhurnal (1999 ) [Ukr Biokhim Zh (1999)] 2012 May-Jun; Vol. 84 (3), pp. 37-43. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Ukrainian |
| بيانات الدورية: | Publisher: Nat︠s︡ionalʹna akademii︠a︡ nauk Ukraïny, Instytut biokhimiï im. O.V. Palladina Country of Publication: Ukraine NLM ID: 101657175 Publication Model: Print Cited Medium: Print NLM ISO Abbreviation: Ukr Biokhim Zh (1999) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kyïv : Nat︠s︡ionalʹna akademii︠a︡ nauk Ukraïny, Instytut biokhimiï im. O.V. Palladina, 1999-2013. |
| مواضيع طبية MeSH: | Antioxidants/*therapeutic use , Catalase/*blood , Diabetes Mellitus, Experimental/*drug therapy , Ethanolamines/*therapeutic use , Nitric Oxide/*blood , Stearic Acids/*therapeutic use , Superoxide Dismutase/*blood, Animals ; Blood Glucose/analysis ; Diabetes Mellitus, Experimental/metabolism ; Male ; Nitrates/blood ; Nitrites/blood ; Rats ; Streptozocin ; Testis/drug effects ; Testis/metabolism ; Thiobarbituric Acid Reactive Substances/analysis |
| مستخلص: | The influence of N-stearoylethanolamine was investigated on the activity of enzymes of antioxidant protection and content of stable metabolites of nitric oxide (NO) in the testes and plasma of rats at the early stages of development of streptozotocine-induced diabetes mellitus. It was shown that the activity of superoxide dismutase, catalase is reduced in the plasma and testes of animals with streptozotocin-induced (50 mg/kg) diabetes (blood glucose 8-10 mmol/L). A significant increase in the amount of nitrite and nitrate anions was revealed in the plasma of rats, while only the level of nitrite was significantly changed in the testes of animals. The per os administration of the NSE aqueous suspension in a dose of 50 mg/kg during 10 days to the rats with induced diabetes contributed to the normalization of catalase activity in the testis, which correlated with a decrease in the amount of TBA-reacting products and activity of superoxide dismutase and catalase in the blood plasma of animals; the use of NSE also contributed to the reduction of nitrite content in the gonads and to normalization of both nitrite and nitrate in the blood plasma of rats. The NSE administration to intact animals caused an increase in superoxide dismutase activity and significantly reduced the content of stable NO metabolites in the blood plasma of animals. |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Blood Glucose) 0 (Ethanolamines) 0 (N-stearoylethanolamine) 0 (Nitrates) 0 (Nitrites) 0 (Stearic Acids) 0 (Thiobarbituric Acid Reactive Substances) 31C4KY9ESH (Nitric Oxide) 5W494URQ81 (Streptozocin) EC 1.11.1.6 (Catalase) EC 1.15.1.1 (Superoxide Dismutase) |
| تواريخ الأحداث: | Date Created: 20120807 Date Completed: 20120821 Latest Revision: 20150803 |
| رمز التحديث: | 20231215 |
| PMID: | 22860400 |
| قاعدة البيانات: | MEDLINE |
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