دورية أكاديمية
Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish.
| العنوان: | Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish. |
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| المؤلفون: | Browning LM; Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, United Kingdom., Walker CG, Mander AP, West AL, Madden J, Gambell JM, Young S, Wang L, Jebb SA, Calder PC |
| المصدر: | The American journal of clinical nutrition [Am J Clin Nutr] 2012 Oct; Vol. 96 (4), pp. 748-58. Date of Electronic Publication: 2012 Aug 29. |
| نوع المنشور: | Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0376027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-3207 (Electronic) Linking ISSN: 00029165 NLM ISO Abbreviation: Am J Clin Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [New York, NY] : Elsevier Original Publication: Bethesda, MD : American Society of Clinical Nutrition |
| مواضيع طبية MeSH: | Diet*/adverse effects , Dietary Supplements*/adverse effects , Fishes* , Lipid Metabolism*, Docosahexaenoic Acids/*metabolism , Eicosapentaenoic Acid/*metabolism , Seafood/*analysis, Adult ; Aged ; Animals ; Biomarkers/blood ; Biomarkers/metabolism ; Blood Platelets/metabolism ; Docosahexaenoic Acids/administration & dosage ; Docosahexaenoic Acids/adverse effects ; Docosahexaenoic Acids/blood ; Double-Blind Method ; Eicosapentaenoic Acid/administration & dosage ; Eicosapentaenoic Acid/adverse effects ; Eicosapentaenoic Acid/blood ; Female ; Humans ; Leukocytes, Mononuclear/metabolism ; Male ; Middle Aged ; Nutrition Assessment ; Phosphatidylcholines/blood ; Phosphatidylcholines/metabolism ; United Kingdom ; Young Adult |
| مستخلص: | Background: Estimation of the intake of oily fish at a population level is difficult. The measurement of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in biological samples may provide a useful biomarker of intake. Objective: We identified the most appropriate biomarkers for the assessment of habitual oily fish intake and changes in intake by elucidating the dose- and time-dependent response of EPA and DHA incorporation into various biological samples that represent roles in fatty acid transport, function, and storage. Design: This was a double-blind, randomized, controlled intervention trial in 204 men and women that lasted 12 mo. EPA and DHA capsules were provided in a manner to reflect sporadic consumption of oily fish (ie, 1, 2, or 4 times/wk). EPA and DHA were assessed at 9 time points over 12 mo in 9 sample types (red blood cells, mononuclear cells, platelets, buccal cells, adipose tissue, plasma phosphatidylcholine, triglycerides, cholesteryl esters, and nonesterified fatty acids). Results: A dose response (P < 0.05) was observed for EPA and DHA in all pools except for red blood cell EPA (P = 0.057). EPA and DHA measures in plasma phosphatidylcholine and platelets were best for the discrimination between different intakes (P < 0.0001). The rate of incorporation varied between sample types, with the time to maximal incorporation ranging from days (plasma phosphatidylcholine) to months (mononuclear cells) to >12 mo (adipose tissue). Conclusions: Plasma phosphatidylcholine EPA plus DHA was identified as the most suitable biomarker of acute changes in EPA and DHA intake, and platelet and mononuclear cell EPA plus DHA were the most suitable biomarkers of habitual intake. |
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| معلومات مُعتمدة: | MC_U105960389 United Kingdom MRC_ Medical Research Council; U1052.00.014 United Kingdom MRC_ Medical Research Council; U105960389 United Kingdom MRC_ Medical Research Council |
| سلسلة جزيئية: | ISRCTN ISRCTN48398526 |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Phosphatidylcholines) 25167-62-8 (Docosahexaenoic Acids) AAN7QOV9EA (Eicosapentaenoic Acid) |
| تواريخ الأحداث: | Date Created: 20120831 Date Completed: 20121207 Latest Revision: 20230318 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC3441107 |
| DOI: | 10.3945/ajcn.112.041343 |
| PMID: | 22932281 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1938-3207 |
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| DOI: | 10.3945/ajcn.112.041343 |