دورية أكاديمية
[Analysis of thyroid homeostasis disorders in patients with severe traumatic brain injury].
| العنوان: | [Analysis of thyroid homeostasis disorders in patients with severe traumatic brain injury]. |
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| المؤلفون: | Shamaeva KhKh, Savin IA, Tenedieva VD, Goriachev AS, Oshorov AV, Sychev AA, Popugaev KA, Sokolova EIu, Polupan AA, Iusupova MM, Potapov AA |
| المصدر: | Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko [Zh Vopr Neirokhir Im N N Burdenko] 2012; Vol. 76 (4), pp. 26-30; discussion 30-1. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Media Sfera Country of Publication: Russia (Federation) NLM ID: 7809757 Publication Model: Print Cited Medium: Print ISSN: 0042-8817 (Print) Linking ISSN: 00428817 NLM ISO Abbreviation: Zh Vopr Neirokhir Im N N Burdenko Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Moskva : Media Sfera Original Publication: Moskva, Meditsina. |
| مواضيع طبية MeSH: | Homeostasis*, Brain Injuries/*blood , Thyroid Diseases/*blood , Thyroid Hormones/*blood, Brain Injuries/complications ; Brain Injuries/drug therapy ; Female ; Humans ; Male ; Thyroid Diseases/drug therapy ; Thyroid Diseases/etiology ; Trauma Severity Indices |
| مستخلص: | Aim of the study was to investigate the status of thyroid homeostasis and the relationship between severe traumatic brain injury (TBI) and thyroid disorders. The study included 56 patients. Protocol of the study concluded: noninvasive and invasive hemodynamic monitoring, including PICCO, transcranial Doppler ultrasonography, measurement of intracranial pressure (ICP), indirect calorimetry, levels of thyroid stimulating hormone (TSH), T3, T4 and free fractions. Patients were divided into three groups. Group 1--with normal thyroid hormones (n = 20), Group 2--with the low T3 (n = 23) and Group 3 with the low T3 and T4 (n = 13). Correlation between the Glasgow Coma Scale (GCS) and thyroid hormone levels was obtained: the first group between GCS and T4 (r = 0.50), GCS, and free fraction T4 (r = 0.51); between the GCS and TSH (r = 0.51), T3 (r = 0.48) and T4 (r = 0.57) in the second group, and the third--with TSH (r = 0.67). Poor outcomes in the first group compound 15%, in the second group--39.2%, and in the third group--62.5% of patients. Doses of vasopressors were significantly higher in groups 2 and 3 compared with a first group. ICP was significantly higher in the group with the low T3 and T4. Development of intracranial hypertension correlated with the formation of thyroid insufficiency. Deficiency of thyroid hormones, especially the simultaneous reduction and T3, and T4 is associated with poor outcome in patients with severe TBI. Doses of sympathomimetic drugs used to optimize the parameters of systemic hemodynamics in acute severe head injury were higher in patients with deficiency of thyroid hormones. |
| المشرفين على المادة: | 0 (Thyroid Hormones) |
| تواريخ الأحداث: | Date Created: 20121005 Date Completed: 20130213 Latest Revision: 20121004 |
| رمز التحديث: | 20231215 |
| PMID: | 23033589 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0042-8817 |
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