دورية أكاديمية
أعرض في EDS

Lack of association between four SNPs in the SLC22A3-LPAL2-LPA gene cluster and coronary artery disease in a Chinese Han population: a case control study.

التفاصيل البيبلوغرافية
العنوان: Lack of association between four SNPs in the SLC22A3-LPAL2-LPA gene cluster and coronary artery disease in a Chinese Han population: a case control study.
المؤلفون: Lv X; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Northern Campus, 74 Zhongshan Road 2, Guangzhou 510080, China., Zhang Y, Rao S, Liu F, Zuo X, Su D, Wang M, Xia M, Guo H, Feng D, Hong C, Li D, Ma W, Ouyang P, Li X, Feng X, Yang Y, Ling W, Qiu J
المصدر: Lipids in health and disease [Lipids Health Dis] 2012 Oct 04; Vol. 11, pp. 128. Date of Electronic Publication: 2012 Oct 04.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101147696 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-511X (Electronic) Linking ISSN: 1476511X NLM ISO Abbreviation: Lipids Health Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2002-
مواضيع طبية MeSH: Polymorphism, Single Nucleotide*, Apolipoprotein A-II/*genetics , Coronary Artery Disease/*genetics , Lipoprotein(a)/*genetics , Organic Cation Transport Proteins/*genetics, Aged ; Case-Control Studies ; China ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Male ; Middle Aged ; Multigene Family
مستخلص: Background: Lipoprotein (a) (Lp [a]) is known being correlated with coronary artery disease (CAD). The SLC22A3-LPAL2-LPA gene cluster, relating with modulating the level of plasma Lp (a), has recently been reported to be associated with CAD in Caucasians. The purpose of this study was to verify whether this finding can be expanded to the Chinese Han population.
Methods and Results: Using a Chinese Han sample, which consisted of 1012 well-characterized CAD patients and 889 healthy controls, we tested the associations of four SNPs (rs2048327, rs3127599, rs7767084 and rs10755578) in the SLC22A3-LPAL2-LPA gene cluster, and their inferred haplotypes with the risk of CAD. Allelic, genotypic and haplotype association analyses all showed that the gene cluster was not associated with CAD in this Chinese Han sample.
Conclusions: We for the first time explored the association of the four SNPs in the SLC22A3-LPAL2-LPA gene cluster with CAD in a large Chinese Han sample. Nevertheless, this study did not reveal any significant evidence of this gene cluster to increase the risk of CAD in this population.
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المشرفين على المادة: 0 (APOA2 protein, human)
0 (Apolipoprotein A-II)
0 (Lipoprotein(a))
0 (Organic Cation Transport Proteins)
0 (solute carrier family 22 (organic cation transporter), member 3)
تواريخ الأحداث: Date Created: 20121006 Date Completed: 20130124 Latest Revision: 20211021
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC3478218
DOI: 10.1186/1476-511X-11-128
PMID: 23036009
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-511X
DOI:10.1186/1476-511X-11-128