دورية أكاديمية
Capillary electrophoresis methods for the analysis of antimalarials. Part I. Chiral separation methods.
| العنوان: | Capillary electrophoresis methods for the analysis of antimalarials. Part I. Chiral separation methods. |
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| المؤلفون: | Amin NC; Laboratoire de Chimie Analytique, Contrôle physico-chimique des médicaments, Institut des Biomolécules Max Mousseron, UMR 5247, Faculté de Pharmacie, BP 14491, 34093 Montpellier, France., Blanchin MD, Aké M, Fabre H |
| المصدر: | Journal of chromatography. A [J Chromatogr A] 2012 Nov 16; Vol. 1264, pp. 1-12. Date of Electronic Publication: 2012 Sep 25. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3778 (Electronic) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, 1993- |
| مواضيع طبية MeSH: | Antimalarials/*isolation & purification , Electrophoresis, Capillary/*methods, Antimalarials/analysis ; Stereoisomerism |
| مستخلص: | This paper presents an overview on the current status of enantiomeric and diastereomeric separations of chiral antimalarials and derivatives by capillary electrophoresis (CE). The wide variety of chiral selectors which have been employed to resolve successfully antimalarial enantiomers: oligosaccharides (cyclodextrins, oligomaltodextrins), neutral (amylose, dextrin and dextran) and charged (chondroitin sulfate, heparin, dextran sulfate) polysaccharides and proteins are reviewed. Cyclodextrins were the most employed. Chiral additives added to the background electrolyte often facilitated separations of quinine/quinidine and cinchonine/cinchonidine diastereomers. However, in a few cases, using micellar electrokinetic capillary chromatography or non aqueous CE, resolution of diastereomers could be achieved without additives. Quantitative applications of CE to the quality control of antimalarial drugs and their analysis in biological and food matrices are presented. (Copyright © 2012 Elsevier B.V. All rights reserved.) |
| المشرفين على المادة: | 0 (Antimalarials) |
| تواريخ الأحداث: | Date Created: 20121016 Date Completed: 20130204 Latest Revision: 20121023 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.chroma.2012.09.057 |
| PMID: | 23063793 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3778 |
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| DOI: | 10.1016/j.chroma.2012.09.057 |