دورية أكاديمية
أعرض في EDS

Central amygdala nucleus (Ce) gene expression linked to increased trait-like Ce metabolism and anxious temperament in young primates.

التفاصيل البيبلوغرافية
العنوان: Central amygdala nucleus (Ce) gene expression linked to increased trait-like Ce metabolism and anxious temperament in young primates.
المؤلفون: Fox AS; Department of Psychology, HealthEmotions Research Institute, University of Wisconsin, Madison, WI 53719, USA. asfox@wisc.edu, Oler JA, Shelton SE, Nanda SA, Davidson RJ, Roseboom PH, Kalin NH
المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Oct 30; Vol. 109 (44), pp. 18108-13. Date of Electronic Publication: 2012 Oct 15.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : National Academy of Sciences
مواضيع طبية MeSH: Gene Expression*, Amygdala/*metabolism , Anxiety/*genetics, Animals ; Macaca mulatta ; Male
مستخلص: Children with anxious temperament (AT) are particularly sensitive to new social experiences and have increased risk for developing anxiety and depression. The young rhesus monkey is optimal for studying the origin of human AT because it shares with humans the genetic, neural, and phenotypic underpinnings of complex social and emotional functioning. In vivo imaging in young monkeys demonstrated that central nucleus of the amygdala (Ce) metabolism is relatively stable across development and predicts AT. Transcriptome-wide gene expression, which reflects combined genetic and environmental influences, was assessed within the Ce. Results support a maladaptive neurodevelopmental hypothesis linking decreased amygdala neuroplasticity to early-life dispositional anxiety. For example, high AT individuals had decreased mRNA expression of neurotrophic tyrosine kinase, receptor, type 3 (NTRK3). Moreover, variation in Ce NTRK3 expression was inversely correlated with Ce metabolism and other AT-substrates. These data suggest that altered amygdala neuroplasticity may play a role the early dispositional risk to develop anxiety and depression.
References: J Neurosci. 2004 Jun 16;24(24):5506-15. (PMID: 15201323)
J Neurosci. 2012 Jan 18;32(3):1073-81. (PMID: 22262905)
Neuropsychopharmacology. 2006 Feb;31(2):287-96. (PMID: 16034442)
J Comp Neurol. 2012 Jun 15;520(9):1965-84. (PMID: 22173686)
Genome Biol. 2004;5(10):R80. (PMID: 15461798)
Neuropsychopharmacology. 2008 Jan;33(1):88-109. (PMID: 17851537)
Biol Psychiatry. 2005 Nov 15;58(10):796-804. (PMID: 16043132)
Nat Neurosci. 2007 Jan;10(1):93-9. (PMID: 17143271)
Ann N Y Acad Sci. 2004 Dec;1032:85-103. (PMID: 15677397)
Science. 2003 Dec 5;302(5651):1710-1. (PMID: 14657487)
Science. 1989 Mar 31;243(4899):1718-21. (PMID: 2564702)
J Neurophysiol. 2004 Jul;92(1):1-9. (PMID: 15212433)
Neuroimage. 2009 Oct 1;47(4):1230-6. (PMID: 19505582)
Ann N Y Acad Sci. 2010 Mar;1191:42-61. (PMID: 20392275)
Science. 2011 Nov 4;334(6056):697-700. (PMID: 22053054)
Nat Rev Neurosci. 2002 Jun;3(6):453-62. (PMID: 12042880)
Biol Psychiatry. 2006 Sep 1;60(5):479-90. (PMID: 16414028)
Mol Psychiatry. 2001 Jan;6(1):13-34. (PMID: 11244481)
Nat Neurosci. 2007 Sep;10(9):1089-93. (PMID: 17726474)
Am J Psychiatry. 2008 May;165(5):610-6. (PMID: 18347002)
J Comp Neurol. 2011 Nov 1;519(16):3218-39. (PMID: 21618234)
Nature. 2011 Mar 17;471(7338):358-62. (PMID: 21389985)
Bioinformatics. 2004 Feb 12;20(3):307-15. (PMID: 14960456)
Prog Neurobiol. 2006 Jul;79(4):205-21. (PMID: 16916571)
Nature. 2010 Aug 12;466(7308):864-8. (PMID: 20703306)
Endocrine. 2006 Jun;29(3):391-8. (PMID: 16943575)
Annu Rev Neurosci. 2002;25:563-93. (PMID: 12052921)
Mol Psychiatry. 2002;7(9):928-30. (PMID: 12399943)
Science. 2007 Jul 20;317(5836):369-72. (PMID: 17641201)
Dev Psychobiol. 2010 Jul;52(5):453-64. (PMID: 20583142)
Ann N Y Acad Sci. 2003 Dec;1008:189-200. (PMID: 14998885)
Diabet Med. 2008 Jul;25(7):878-81. (PMID: 18644077)
Nature. 2010 Nov 11;468(7321):277-82. (PMID: 21068837)
Diabetologia. 2003 Dec;46(12):1604-10. (PMID: 14595538)
Annu Rev Psychol. 2005;56:235-62. (PMID: 15709935)
Cereb Cortex. 2012 Aug;22(8):1717-27. (PMID: 21955917)
J Neurosci. 2007 Mar 21;27(12):3295-304. (PMID: 17376990)
Diabetes Care. 2001 Jun;24(6):1069-78. (PMID: 11375373)
J Biol Chem. 1997 Nov 28;272(48):30334-9. (PMID: 9374521)
Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4176-9. (PMID: 15753316)
Science. 2007 Apr 13;316(5822):222-34. (PMID: 17431167)
Learn Mem. 2011 May 19;18(6):375-83. (PMID: 21597043)
Rev Neurosci. 2005;16(4):287-302. (PMID: 16519006)
Neuron. 2011 May 26;70(4):687-702. (PMID: 21609825)
Neuron. 1999 Jun;23(2):229-32. (PMID: 10399930)
Science. 1988 Apr 8;240(4849):167-71. (PMID: 3353713)
Neuron. 2009 Jun 25;62(6):757-71. (PMID: 19555645)
Mol Psychiatry. 2000 Nov;5(6):578-93. (PMID: 11126389)
Genes Brain Behav. 2008 Oct;7(7):778-85. (PMID: 18616610)
Psychiatry Res. 2011 Feb 28;185(3):358-62. (PMID: 20554328)
Diabetes Care. 1997 Apr;20(4):585-90. (PMID: 9096984)
Annu Rev Cell Dev Biol. 2011;27:697-729. (PMID: 21740233)
Am J Psychiatry. 2001 Oct;158(10):1673-9. (PMID: 11579001)
PLoS One. 2008 Jul 02;3(7):e2570. (PMID: 18596957)
Cell. 1991 Sep 6;66(5):967-79. (PMID: 1653651)
Am J Psychiatry. 2010 Jan;167(1):40-6. (PMID: 19917594)
Nat Neurosci. 2011 Nov 20;15(1):13-9. (PMID: 22101646)
Trends Neurosci. 1998 Aug;21(8):323-31. (PMID: 9720596)
Nature. 2010 Nov 11;468(7321):270-6. (PMID: 21068836)
Neuron. 2009 Sep 10;63(5):614-27. (PMID: 19755105)
Proc Natl Acad Sci U S A. 2011 May 10;108(19):8021-5. (PMID: 21518861)
Drug Discov Today. 2009 Jul;14(13-14):690-7. (PMID: 19460458)
Neuron. 2001 Sep 13;31(5):841-51. (PMID: 11567621)
Endocrine. 2003 Jul;21(2):115-22. (PMID: 12897373)
معلومات مُعتمدة: MH018931 United States MH NIMH NIH HHS; R21 MH091550 United States MH NIMH NIH HHS; P50 MH084051 United States MH NIMH NIH HHS; P51RR000167 United States RR NCRR NIH HHS; HD003352 United States HD NICHD NIH HHS; T32 MH018931 United States MH NIMH NIH HHS; MH046729 United States MH NIMH NIH HHS; R01 MH046729 United States MH NIMH NIH HHS; HD008352 United States HD NICHD NIH HHS; P51 RR000167 United States RR NCRR NIH HHS; P30 HD003352 United States HD NICHD NIH HHS; F32 HD008352 United States HD NICHD NIH HHS; MH081884 United States MH NIMH NIH HHS; MH91550 United States MH NIMH NIH HHS; R01 MH081884 United States MH NIMH NIH HHS; MH084051 United States MH NIMH NIH HHS; P51 OD011106 United States OD NIH HHS; P51OD011106 United States OD NIH HHS
تواريخ الأحداث: Date Created: 20121017 Date Completed: 20130108 Latest Revision: 20240418
رمز التحديث: 20240418
مُعرف محوري في PubMed: PMC3497741
DOI: 10.1073/pnas.1206723109
PMID: 23071305
قاعدة البيانات: MEDLINE
الوصف
تدمد:1091-6490
DOI:10.1073/pnas.1206723109