دورية أكاديمية
Challenges and controversies in defining totally drug-resistant tuberculosis.
| العنوان: | Challenges and controversies in defining totally drug-resistant tuberculosis. |
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| المؤلفون: | Cegielski P; Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Nunn P, Kurbatova EV, Weyer K, Dalton TL, Wares DF, Iademarco MF, Castro KG, Raviglione M |
| المصدر: | Emerging infectious diseases [Emerg Infect Dis] 2012 Nov; Vol. 18 (11), pp. e2. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995- |
| مواضيع طبية MeSH: | Tuberculosis, Multidrug-Resistant*/drug therapy, Humans ; Terminology as Topic |
| مستخلص: | In March 2012, in response to reports of tuberculosis (TB) resistant to all anti-TB drugs, the World Health Organization convened an expert consultation that identified issues to be resolved before defining a new category of highly drug-resistant TB. Proposed definitions are ambiguous, and extensive drug resistance is encompassed by the already defined extensively drug-resistant (XDR) TB. There is no evidence that proposed totally resistant TB differs from strains encompassed by XDR TB. Susceptibility tests for several drugs are poorly reproducible. Few laboratories can test all drugs, and there is no consensus list of all anti-TB drugs. Many drugs are used off-label for highly drug resistant TB, and new drugs formulated to combat resistant strains would render the proposed category obsolete. Labeling TB strains as totally drug resistant might lead providers to think infected patients are untreatable. These challenges must be addressed before defining a new category for highly drug-resistant TB. |
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| تواريخ الأحداث: | Date Created: 20121025 Date Completed: 20130411 Latest Revision: 20220129 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC3559144 |
| DOI: | 10.3201/eid1811.120526 |
| PMID: | 23092736 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1080-6059 |
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| DOI: | 10.3201/eid1811.120526 |