دورية أكاديمية
[Combined therapy of membranoproliferative glomerulonephritis in older patients].
| العنوان: | [Combined therapy of membranoproliferative glomerulonephritis in older patients]. |
|---|---|
| المؤلفون: | Boterashvili DI, Esaian AM, Rumiantsev ASh, Sovetkina NV |
| المصدر: | Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2012; Vol. 25 (2), pp. 280-4. |
| نوع المنشور: | Clinical Trial; English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Ėskulap Country of Publication: Russia (Federation) NLM ID: 100971443 Publication Model: Print Cited Medium: Print ISSN: 1561-9125 (Print) Linking ISSN: 15619125 NLM ISO Abbreviation: Adv Gerontol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Sankt-Peterburg : Ėskulap, |
| مواضيع طبية MeSH: | Cyclophosphamide*/administration & dosage , Cyclophosphamide*/adverse effects , Glomerulonephritis, Membranoproliferative*/blood , Glomerulonephritis, Membranoproliferative*/complications , Glomerulonephritis, Membranoproliferative*/drug therapy , Glomerulonephritis, Membranoproliferative*/pathology , Glomerulonephritis, Membranoproliferative*/physiopathology , Prednisolone*/administration & dosage , Prednisolone*/adverse effects, Nephrotic Syndrome/*etiology, Aged ; Antineoplastic Agents, Alkylating/administration & dosage ; Antineoplastic Agents, Alkylating/adverse effects ; Biopsy ; Dose-Response Relationship, Drug ; Drug Monitoring/methods ; Female ; Glucocorticoids/administration & dosage ; Glucocorticoids/adverse effects ; Humans ; Kidney Function Tests/methods ; Male ; Nephrotic Syndrome/blood ; Nephrotic Syndrome/drug therapy ; Nephrotic Syndrome/physiopathology ; Remission Induction ; Severity of Illness Index ; Time ; Treatment Outcome |
| مستخلص: | The aim of the study was to investigate the effectiveness of combined long-term therapy by cytostatics and steroid hormones in older patients with membranoproliferative glomerulonephritis to halt renal failure progression. 27 patients older than 60 years with morphologically proved membranoproliferative glomerulonephritis have been treated. Nephrosclerosis was detected in 40% of studied patients according to results of kidney biopsies. The mean age of the patients was 65.8 +/- 1.5 years. The activity of the disease depended on presence and severity of nephrotic syndrome. 17 (62.9%) patients had coronary heart disease, 7 (25.9%) patients had chronic bronchitis, 7 (25.9%) patients had peptic ulcer disease in a remission phase. Patients received therapy by cyclophosphamide in a dose of 2 mg/kg daily and prednisolone in a dose of 1 mg/kg daily during 2 years. Tolerability of assigned treatment was satisfactory. The main clinical and laboratory signs of nephrotic syndrome were significantly reduced and the proof remission was reached after 8-12 months of combined therapy. During the observation (24 month) the glomerular filtration rate in studied patients didn't decreased over 30-59 mL/min/1.73 m2 and corresponded to stage 3 of chronic kidney disease. |
| المشرفين على المادة: | 0 (Antineoplastic Agents, Alkylating) 0 (Glucocorticoids) 8N3DW7272P (Cyclophosphamide) 9PHQ9Y1OLM (Prednisolone) |
| تواريخ الأحداث: | Date Created: 20121108 Date Completed: 20121217 Latest Revision: 20161021 |
| رمز التحديث: | 20231215 |
| PMID: | 23130519 |
| قاعدة البيانات: | MEDLINE |
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