دورية أكاديمية
أعرض في EDS

Histological criteria for encapsulating peritoneal sclerosis - a standardized approach.

التفاصيل البيبلوغرافية
العنوان: Histological criteria for encapsulating peritoneal sclerosis - a standardized approach.
المؤلفون: Braun N; Department of Internal Medicine, Division of Nephrology, Robert Bosch Hospital, Stuttgart, Germany., Fritz P, Ulmer C, Latus J, Kimmel M, Biegger D, Ott G, Reimold F, Thon KP, Dippon J, Segerer S, Alscher MD
المصدر: PloS one [PLoS One] 2012; Vol. 7 (11), pp. e48647. Date of Electronic Publication: 2012 Nov 07.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Peritoneal Fibrosis/*pathology , Statistics as Topic/*methods, Female ; Humans ; Male ; Middle Aged ; Observer Variation ; Peritoneal Dialysis/adverse effects ; Peritoneal Fibrosis/classification ; Sclerosis/pathology
مستخلص: Background: The two most relevant pathologies of long-term peritoneal dialysis (PD) are simple sclerosis and encapsulating peritoneal sclerosis (EPS). The histological differentiation of those two entities is difficult. The Aim of the study was to establish a method to standardize and facilitate the differentiation between simple sclerosis and EPS METHODS: We investigated 58 peritoneal biopsies - 31 EPS patients and 27 PD patients. Two blinded investigators analyzed 20 histological characteristics in EPS and PD patients.
Results: THE FOLLOWING FINDINGS WERE SIGNIFICANTLY MORE COMMON IN EPS THAN IN PATIENTS ON PD WITHOUT EPS: fibroblast like cells (FLC) (p<0.0001), mesothelial denudation (p<0.0001), decreased cellularity (p = 0.008), fibrin deposits (p<0.03), Fe deposits (p = 0.05), podoplanin vascular (p<0.0001), podoplanin avascular (p<0.0001). Using all predictor variables we trained the classification method Random Forest to categorize future cases. Podoplanin vascular and avascular were taken together (p<0.0001), FLC (p<0.0001), mesothelial denudation (p = 0.0005), calcification (p = 0.0026), acellular areas (p = 0.0094), and fibrin deposits (p = 0.0336) showed up as significantly important predictor variables. Estimated misclassification error rate when classifying new cases turned out to be 14%.
Conclusion: The introduced statistical method allows discriminating between simple sclerosis and EPS. The misclassification error will likely improve with every new case added to the database.
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تواريخ الأحداث: Date Created: 20121113 Date Completed: 20130424 Latest Revision: 20211021
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3492493
DOI: 10.1371/journal.pone.0048647
PMID: 23144917
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0048647