دورية أكاديمية
Short chain fatty acids and their receptors: new metabolic targets.
| العنوان: | Short chain fatty acids and their receptors: new metabolic targets. |
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| المؤلفون: | Layden BT; Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611-3008, USA. b-layden@northwestern.edu, Angueira AR, Brodsky M, Durai V, Lowe WL Jr |
| المصدر: | Translational research : the journal of laboratory and clinical medicine [Transl Res] 2013 Mar; Vol. 161 (3), pp. 131-40. Date of Electronic Publication: 2012 Nov 09. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101280339 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1810 (Electronic) Linking ISSN: 18781810 NLM ISO Abbreviation: Transl Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, N.Y. : Elsevier, [2006]- |
| مواضيع طبية MeSH: | Fatty Acids, Volatile/*metabolism , Receptors, Cell Surface/*metabolism , Receptors, G-Protein-Coupled/*metabolism, Animals ; Cholesterol/metabolism ; Digestive System/metabolism ; Digestive System/microbiology ; Fatty Acids, Volatile/chemistry ; Glucose/metabolism ; Humans ; Insulin/metabolism ; Lipid Metabolism ; Obesity/metabolism ; Signal Transduction ; Translational Research, Biomedical |
| مستخلص: | Fatty acids are carboxylic acids with aliphatic tails of different lengths, where short chain fatty acids (SCFAs) typically refer to carboxylic acids with aliphatic tails less than 6 carbons. In humans, SCFAs are derived in large part from fermentation of carbohydrates and proteins in the colon. By this process, the host is able to salvage energy from foods that cannot be processed normally in the upper parts of the gastrointestinal tract. In humans, SCFAs are a minor nutrient source, especially for people on Western diets. Intriguingly, recent studies, as highlighted here, have described multiple beneficial roles of SCFAs in the regulation of metabolism. Further interest in SCFAs has emerged due to the association of gut flora composition with obesity and other metabolic states. The recent identification of receptors specifically activated by SCFAs has further increased interest in this area. These receptors, free fatty acid receptor-2 and -3 (FFAR2 and FFAR3), are expressed not only in the gut epithelium where SCFAs are produced, but also at multiple other sites considered to be metabolically important, such as adipose tissue and pancreatic islets. Because of these relatively recent findings, studies examining the role of these receptors, FFAR2 and FFAR3, and their ligands, SCFAs, in metabolism are emerging. This review provides a critical analysis of SCFAs, their recently identified receptors, and their connection to metabolism. (Published by Mosby, Inc.) |
| التعليقات: | Erratum in: Transl Res. 2013 Oct;162(4):269. |
| معلومات مُعتمدة: | K12 HD044405 United States HD NICHD NIH HHS |
| المشرفين على المادة: | 0 (FFA2R protein, human) 0 (FFAR3 protein, human) 0 (Fatty Acids, Volatile) 0 (Insulin) 0 (Receptors, Cell Surface) 0 (Receptors, G-Protein-Coupled) 97C5T2UQ7J (Cholesterol) IY9XDZ35W2 (Glucose) |
| تواريخ الأحداث: | Date Created: 20121114 Date Completed: 20130419 Latest Revision: 20220408 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.trsl.2012.10.007 |
| PMID: | 23146568 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1878-1810 |
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| DOI: | 10.1016/j.trsl.2012.10.007 |