دورية أكاديمية
TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes.
| العنوان: | TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. |
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| المؤلفون: | Bai X; Stem Cell Program, Children's Hospital Boston, Boston, MA 02115, USA., Trowbridge JJ, Riley E, Lee JA, DiBiase A, Kaartinen VM, Orkin SH, Zon LI |
| المصدر: | Developmental biology [Dev Biol] 2013 Jan 15; Vol. 373 (2), pp. 422-30. Date of Electronic Publication: 2012 Nov 16. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0372762 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-564X (Electronic) Linking ISSN: 00121606 NLM ISO Abbreviation: Dev Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: San Diego, CA : Elsevier Original Publication: New York. |
| مواضيع طبية MeSH: | Gene Expression Regulation, Developmental* , Transcription Elongation, Genetic*, Erythroid Cells/*metabolism , Hematopoiesis/*genetics , Transcription Factors/*metabolism, Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/metabolism ; Bone Marrow Cells/cytology ; Bone Marrow Cells/metabolism ; Cell Differentiation/genetics ; Cell Lineage/genetics ; Erythroid Cells/cytology ; Gene Deletion ; Granulocyte-Macrophage Progenitor Cells/cytology ; Granulocyte-Macrophage Progenitor Cells/metabolism ; Granulocytes/cytology ; Granulocytes/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myelopoiesis/genetics ; Spleen/metabolism ; Transcription Factors/deficiency |
| مستخلص: | Transcriptional regulators play critical roles in the regulation of cell fate during hematopoiesis. Previous studies in zebrafish have identified an essential role for the transcriptional intermediary factor TIF1γ in erythropoiesis by regulating the transcription elongation of erythroid genes. To study if TIF1γ plays a similar role in murine erythropoiesis and to assess its function in other blood lineages, we generated mouse models with hematopoietic deletion of TIF1γ. Our results showed a block in erythroid maturation in the bone marrow following tif1γ deletion that was compensated with enhanced spleen erythropoiesis. Further analyses revealed a defect in transcription elongation of erythroid genes in the bone marrow. In addition, loss of TIF1γ resulted in defects in other blood compartments, including a profound loss of B cells, a dramatic expansion of granulocytes and decreased HSC function. TIF1γ exerts its functions in a cell-autonomous manner as revealed by competitive transplantation experiments. Our study therefore demonstrates that TIF1γ plays essential roles in multiple murine blood lineages and that its function in transcription elongation is evolutionally conserved. (Published by Elsevier Inc.) |
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| معلومات مُعتمدة: | R00 DK088963 United States DK NIDDK NIH HHS; R01 HL032259 United States HL NHLBI NIH HHS; P30 DK049216 United States DK NIDDK NIH HHS; P01 HL032262 United States HL NHLBI NIH HHS; P01HL32262 United States HL NHLBI NIH HHS; R01 HL048801 United States HL NHLBI NIH HHS; K99DK088963 United States DK NIDDK NIH HHS; K99 DK088963 United States DK NIDDK NIH HHS; United States HHMI_ Howard Hughes Medical Institute |
| المشرفين على المادة: | 0 (Transcription Factors) 0 (Trim33 protein, mouse) |
| تواريخ الأحداث: | Date Created: 20121120 Date Completed: 20130221 Latest Revision: 20220129 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC3540997 |
| DOI: | 10.1016/j.ydbio.2012.10.008 |
| PMID: | 23159334 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1095-564X |
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| DOI: | 10.1016/j.ydbio.2012.10.008 |