دورية أكاديمية
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis.
| العنوان: | Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis. |
|---|---|
| المؤلفون: | Neves Ede S; Laboratório de Pesquisa Clínica em Doenças Febris Agudas, Instituto de Pesquisa Clinica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ. elizabeth.neves@ipec.fiocruz.br, Curi AL, Albuquerque MC, Palhano-Silva CS, Silva LB, Bueno WF, Amendoeira MR, Bonecini-Almeida Mda G, Fernandes O |
| المصدر: | Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2012 Dec; Vol. 45 (6), pp. 757-60. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sociedade Brasileira de Medicina Tropical Country of Publication: Brazil NLM ID: 7507456 Publication Model: Print Cited Medium: Internet ISSN: 1678-9849 (Electronic) Linking ISSN: 00378682 NLM ISO Abbreviation: Rev Soc Bras Med Trop Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <1997-> : Uberaba, MG, Brazil : Sociedade Brasileira de Medicina Tropical Original Publication: Rio De Janeiro : Sociedade Brasileira De Medicina Tropical |
| مواضيع طبية MeSH: | Gene Frequency*, Chorioretinitis/*parasitology , Interferon-gamma/*genetics , Polymorphism, Single Nucleotide/*genetics , Toxoplasmosis/*genetics, Acute Disease ; Adult ; Case-Control Studies ; Chorioretinitis/genetics ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Severity of Illness Index ; Toxoplasmosis, Ocular/genetics |
| مستخلص: | Introduction: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis. Methods: A case-control study was conducted among 30 patients and 90 controls. Results: Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease. Conclusions: Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis. |
| المشرفين على المادة: | 82115-62-6 (Interferon-gamma) |
| تواريخ الأحداث: | Date Created: 20130109 Date Completed: 20130725 Latest Revision: 20190907 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1590/s0037-86822012000600020 |
| PMID: | 23295883 |
| قاعدة البيانات: | MEDLINE |
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