دورية أكاديمية
Effect of renal impairment on distribution of ofloxacin.
| العنوان: | Effect of renal impairment on distribution of ofloxacin. |
|---|---|
| المؤلفون: | Sanchez Navarro A; Department of Pharmacy and Pharmaceutical Technology, University of Salamanca, Spain., Martinez Lanao J, Sanchez Recio MM, Domínguez-Gil Hurlé A, Tabernero Romo JM, Gomez Sanchez JC, Terreiro Delgado MM |
| المصدر: | Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1990 Mar; Vol. 34 (3), pp. 455-9. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print Cited Medium: Print ISSN: 0066-4804 (Print) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Society for Microbiology |
| مواضيع طبية MeSH: | Kidney/*metabolism , Kidney Diseases/*metabolism , Ofloxacin/*pharmacokinetics, Adult ; Blister/metabolism ; Extracellular Space/metabolism ; Humans ; Ofloxacin/blood |
| مستخلص: | A study was made of the plasma and distribution kinetics of ofloxacin administered at a dosage of 400 mg orally to a group of healthy volunteers and a group of patients with renal impairment. Blood and blister fluid samples were taken at programmed times from all individuals included in the study. The analytical techniques for the determination of ofloxacin in both fluids were a plate diffusion method and a high-performance liquid chromatographic technique. The fitting of the experimental data to the kinetic model used was done with the help of the AUTOAN 2 and NONLIN 84 computer programs. In the groups of healthy volunteers, the elimination half-life mean values were found to be 5.1 and 5.9 h in plasma and blister fluid, respectively. The maximum concentration reached in plasma (3.9 micrograms/ml) proved to be slightly higher than that in interstitial tissue fluid (2.8 micrograms/ml). In the patients with renal impairment, the maximum concentrations in both plasma and blister fluid were significantly increased, in the order of 5 to 8 micrograms/ml in the former and 3 to 4 micrograms/ml in interstitial tissue fluid. The parameters seen to undergo an increase as a result of the renal impairment were the area under the curve of the plasma-time levels, the area under the curve of the blister fluid-time levels, and the elimination half-life in plasma and blister fluid. The degree of absorption and the access capacity of the drug to interstitial tissue fluid remained constant. |
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| المشرفين على المادة: | A4P49JAZ9H (Ofloxacin) |
| تواريخ الأحداث: | Date Created: 19900301 Date Completed: 19900606 Latest Revision: 20210526 |
| رمز التحديث: | 20240627 |
| مُعرف محوري في PubMed: | PMC171614 |
| DOI: | 10.1128/AAC.34.3.455 |
| PMID: | 2334157 |
| قاعدة البيانات: | MEDLINE |
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