دورية أكاديمية

Natural products as a source for treating neglected parasitic diseases.

التفاصيل البيبلوغرافية
العنوان: Natural products as a source for treating neglected parasitic diseases.
المؤلفون: Ndjonka D; Department of Biological Sciences, Faculty of Science, University of Ngaoundere, B. P. 454, Cameroon. liebaue@uni-muenster.de., Rapado LN, Silber AM, Liebau E, Wrenger C
المصدر: International journal of molecular sciences [Int J Mol Sci] 2013 Feb 06; Vol. 14 (2), pp. 3395-439. Date of Electronic Publication: 2013 Feb 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Print ISSN: 1422-0067 (Print) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مستخلص: Infectious diseases caused by parasites are a major threat for the entire mankind, especially in the tropics. More than 1 billion people world-wide are directly exposed to tropical parasites such as the causative agents of trypanosomiasis, leishmaniasis, schistosomiasis, lymphatic filariasis and onchocerciasis, which represent a major health problem, particularly in impecunious areas. Unlike most antibiotics, there is no "general" antiparasitic drug available. Here, the selection of antiparasitic drugs varies between different organisms. Some of the currently available drugs are chemically de novo synthesized, however, the majority of drugs are derived from natural sources such as plants which have subsequently been chemically modified to warrant higher potency against these human pathogens. In this review article we will provide an overview of the current status of plant derived pharmaceuticals and their chemical modifications to target parasite-specific peculiarities in order to interfere with their proliferation in the human host.
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تواريخ الأحداث: Date Created: 20130208 Date Completed: 20130208 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3588050
DOI: 10.3390/ijms14023395
PMID: 23389040
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms14023395