دورية أكاديمية
أعرض في EDS

Adverse drug events in a paediatric intensive care unit: a prospective cohort.

التفاصيل البيبلوغرافية
العنوان: Adverse drug events in a paediatric intensive care unit: a prospective cohort.
المؤلفون: Silva DC; Faculty of Medicine, Instituto da Criança, University of Sao Paulo, FMUSP, Sao Paulo, Sao Paulo, Brazil., Araujo OR, Arduini RG, Alonso CF, Shibata AR, Troster EJ
المصدر: BMJ open [BMJ Open] 2013 Feb 19; Vol. 3 (2). Date of Electronic Publication: 2013 Feb 19 (Print Publication: 2013).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic-Print Cited Medium: Print ISSN: 2044-6055 (Print) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : BMJ Publishing Group Ltd, 2011-
مستخلص: Objectives: To describe adverse drug events (ADEs) in children under intensive care, identify risk factors and tools that can detect ADEs early, and the impact on length of stay (LOS).
Design: A prospective observational study.
Setting: Paediatric intensive care unit of a tertiary care teaching hospital.
Patients: 239 patients with a mean age of 67.5 months representing 1818 days of hospitalisation in intensive care unit.
Interventions: Active search of charts and electronic patient records using triggers. The statistical analysis involved linear and logistic regression.
Measurements and Main Results: The average LOS was 7.6 days. There were 110 proven, probable and possible ADEs in 84 patients (35.1%). We observed 138 instances of triggers. The major classes of drugs associated with events were: antibiotics (n=41), diuretics (n=24), antiseizures (n=23), sedatives and analgesics (n=17) and steroids (n=18). The number of drugs administered was most related to the occurrence of ADEs and also to the LOS (p<0.001). The occurrence of an ADE may result in an increase in the LOS by 1.5 days per event, but this was not statistically significant in this sample. Patients aged less than 48 months also proved to be at a significant risk for ADEs, with an OR of 1.84 (95% CI 1.07 to 3.15, p=0.025). The number of drugs administered also correlated with the number of ADEs (p<0.0001). The chance of having at least one ADE increased linearly as the patient was administered more drugs.
Conclusions: The use of multiple drugs as well as lower patient age favours the occurrence of ADEs. The active search described here provides a systematic approach to this problem.
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تواريخ الأحداث: Date Created: 20130222 Date Completed: 20130221 Latest Revision: 20211021
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC3586175
DOI: 10.1136/bmjopen-2012-001868
PMID: 23427200
قاعدة البيانات: MEDLINE
الوصف
تدمد:2044-6055
DOI:10.1136/bmjopen-2012-001868