دورية أكاديمية
Association between rs10118757(A/G) in methylthioadenosine phosphorylase gene and coronary artery disease in Chinese Hans.
| العنوان: | Association between rs10118757(A/G) in methylthioadenosine phosphorylase gene and coronary artery disease in Chinese Hans. |
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| المؤلفون: | Lv X; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University (Northern Campus), 74 Zhongshan Road 2, Guangzhou, 510080, China. lvxfei@mail3.sysu.edu.cn, Zhang Y, Rao S, Su D, Feng D, Wang M, Li X, Li D, Guo H, Zuo X, Xia M, Ouyang H, Ling W, Qiu J |
| المصدر: | Gene [Gene] 2013 Sep 10; Vol. 526 (2), pp. 344-6. Date of Electronic Publication: 2013 Feb 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland, 1976- |
| مواضيع طبية MeSH: | Genetic Predisposition to Disease* , Polymorphism, Single Nucleotide*, Asian People/*genetics , Coronary Artery Disease/*genetics , Purine-Nucleoside Phosphorylase/*genetics, Aged ; Alleles ; China ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Risk Factors |
| مستخلص: | Studies focusing on the association of gene methylthioadenosine phosphorylase (MTAP) with the risk of coronary artery disease (CAD) and myocardial infarction (MI) are limited. In this study, we explored the effects of rs10118757 in MTAP gene on CAD and MI by performing association analysis in a Chinese Han population. rs10118757 was genotyped in 1007 CAD patients (including 338 MI patients) and 885 healthy controls. Allelic analysis showed that allele A of rs10118757 was associated with increased risk of CAD, with OR (95%CI)=1.193 (1.035-1.376), and P=0.015. After adjusted for age, BMI, gender, hypertension and smoking, rs10118757 was still significantly associated with CAD under additive and dominant models, with OR (95%CI)=1.252 (1.070-1.465), P=0.005, and OR (95%CI)=1.698 (1.168-2.467), P=0.006, respectively. Compared to additive model, dominant model may be the best-fitting model (P=6.63E-10 vs P=6.70E-10). As reported previously, rs10118757 was not associated with MI in the current study. Our study firstly reported that SNP rs10118757 was associated with CAD risk in a Chinese Han population, indicating that MTAP gene may play a potential role in the pathophysiological process of CAD. (Copyright © 2013 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Association analysis; BMI; CABG; CAD; CI; Chinese Han population; DNA; IFN-γ; MAF; MI; MTAP; OR; PTCA; S-adenosylhomocysteine; S-adenosylmethionine; SAH; SAM; SNP; body mass index; confidence interval; coronary artery bypass graft surgery; coronary artery disease; deoxyribonucleic acid; interferon-γ; methylthioadenosine phosphorylase; minor allele frequency; myocardial infarction; odds ratio; percutaneous transluminal coronary angioplasty; single nucleotide polymorphism |
| المشرفين على المادة: | EC 2.4.2.1 (Purine-Nucleoside Phosphorylase) EC 2.4.2.28 (5'-methylthioadenosine phosphorylase) |
| تواريخ الأحداث: | Date Created: 20130307 Date Completed: 20131018 Latest Revision: 20221207 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.gene.2013.02.013 |
| PMID: | 23462334 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0038 |
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| DOI: | 10.1016/j.gene.2013.02.013 |