دورية أكاديمية
أعرض في EDS

Dynamic epigenetic regulation of gene expression during the life cycle of malaria parasite Plasmodium falciparum.

التفاصيل البيبلوغرافية
العنوان: Dynamic epigenetic regulation of gene expression during the life cycle of malaria parasite Plasmodium falciparum.
المؤلفون: Gupta AP; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Chin WH, Zhu L, Mok S, Luah YH, Lim EH, Bozdech Z
المصدر: PLoS pathogens [PLoS Pathog] 2013 Feb; Vol. 9 (2), pp. e1003170. Date of Electronic Publication: 2013 Feb 28.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science, c2005-
مواضيع طبية MeSH: Epigenesis, Genetic* , Gene Expression Regulation, Developmental*, Life Cycle Stages/*physiology , Plasmodium falciparum/*genetics, Animals ; Genome, Protozoan ; Histones/genetics ; Real-Time Polymerase Chain Reaction ; Time Factors ; Transcription, Genetic
مستخلص: Epigenetic mechanisms are emerging as one of the major factors of the dynamics of gene expression in the human malaria parasite, Plasmodium falciparum. To elucidate the role of chromatin remodeling in transcriptional regulation associated with the progression of the P. falciparum intraerythrocytic development cycle (IDC), we mapped the temporal pattern of chromosomal association with histone H3 and H4 modifications using ChIP-on-chip. Here, we have generated a broad integrative epigenomic map of twelve histone modifications during the P. falciparum IDC including H4K5ac, H4K8ac, H4K12ac, H4K16ac, H3K9ac, H3K14ac, H3K56ac, H4K20me1, H4K20me3, H3K4me3, H3K79me3 and H4R3me2. While some modifications were found to be associated with the vast majority of the genome and their occupancy was constant, others showed more specific and highly dynamic distribution. Importantly, eight modifications displaying tight correlations with transcript levels showed differential affinity to distinct genomic regions with H4K8ac occupying predominantly promoter regions while others occurred at the 5' ends of coding sequences. The promoter occupancy of H4K8ac remained unchanged when ectopically inserted at a different locus, indicating the presence of specific DNA elements that recruit histone modifying enzymes regardless of their broad chromatin environment. In addition, we showed the presence of multivalent domains on the genome carrying more than one histone mark, highlighting the importance of combinatorial effects on transcription. Overall, our work portrays a substantial association between chromosomal locations of various epigenetic markers, transcriptional activity and global stage-specific transitions in the epigenome.
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المشرفين على المادة: 0 (Histones)
تواريخ الأحداث: Date Created: 20130308 Date Completed: 20130912 Latest Revision: 20211021
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC3585154
DOI: 10.1371/journal.ppat.1003170
PMID: 23468622
قاعدة البيانات: MEDLINE
الوصف
تدمد:1553-7374
DOI:10.1371/journal.ppat.1003170