دورية أكاديمية
أعرض في EDS

Glycaemic index, carbohydrate substitution for fat and risk of CHD in men.

التفاصيل البيبلوغرافية
العنوان: Glycaemic index, carbohydrate substitution for fat and risk of CHD in men.
المؤلفون: Similä ME; Division of Welfare and Health Promotion, National Institute for Health and Welfare, PO Box 30, FI-00271 Helsinki, Finland., Kontto JP, Männistö S, Valsta LM, Virtamo J
المصدر: The British journal of nutrition [Br J Nutr] 2013 Nov 14; Vol. 110 (9), pp. 1704-11. Date of Electronic Publication: 2013 Mar 27.
نوع المنشور: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
اللغة: English
بيانات الدورية: Publisher: Published on behalf of the Nutrition Society by CABI Publishing Country of Publication: England NLM ID: 0372547 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-2662 (Electronic) Linking ISSN: 00071145 NLM ISO Abbreviation: Br J Nutr Subsets: MEDLINE
أسماء مطبوعة: Publication: <2000->: Wallingford, Oxon, UK : Published on behalf of the Nutrition Society by CABI Publishing
Original Publication: [Cambridge, New York] Cambridge University Press.
مواضيع طبية MeSH: Diet* , Dietary Carbohydrates*/adverse effects , Dietary Carbohydrates*/metabolism , Dietary Carbohydrates*/pharmacology , Dietary Fats*/adverse effects , Dietary Fats*/pharmacology , Energy Intake* , Fatty Acids*/adverse effects , Fatty Acids*/pharmacology , Glycemic Index*, Coronary Disease/*prevention & control, Aged ; Coronary Disease/etiology ; Coronary Disease/mortality ; Diet Surveys ; Fatty Acids, Monounsaturated/pharmacology ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Myocardial Infarction/etiology ; Myocardial Infarction/prevention & control ; Proportional Hazards Models ; Risk Factors ; Surveys and Questionnaires ; Trans Fatty Acids/adverse effects
مستخلص: We have examined the associations between dietary glycaemic index (GI), substitutions of total, low-, medium- and high-GI carbohydrates for fat and the risk of CHD. The study consisted of 21 955 male smokers, aged 50-69 years, within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. The diet was assessed at baseline using a validated FFQ. During a 19-year follow-up, 4379 CHD cases (2377 non-fatal myocardial infarctions and 2002 CHD deaths) were identified from national registers. Relative risks (RR) and CI for CHD were analysed using Cox proportional hazards modelling, and multivariate nutrient density models were applied to examine the associations between the substitutions of macronutrients and the risk of CHD. Dietary GI was inversely associated with CHD risk: multivariate RR in the highest v. lowest quintile was 0·89 (95 % CI 0·81, 0·99). Replacement of higher-GI carbohydrates with lower-GI carbohydrates did not associate with the risk. Replacing saturated and trans-fatty acids with carbohydrates was associated with decreased CHD risk: RR for substitution of 2 % of energy intake was 0·97 (95 % CI 0·94, 0·99). On the contrary, replacing MUFA with carbohydrates was associated with an increased risk: RR for substitution of 2 % of energy intake was 1·08 (95 % CI 1·01, 1·16). We conclude that in the present study population, contrary to the hypothesis, a lower GI does not associate with a decreased risk of CHD. The associations of carbohydrates with CHD risk depend on the fatty acid composition of the diet.
معلومات مُعتمدة: N01-CN-45165 United States CN NCI NIH HHS; N01-RC-37004 United States RC CCR NIH HHS; N01-RC-45035 United States RC CCR NIH HHS
المشرفين على المادة: 0 (Dietary Carbohydrates)
0 (Dietary Fats)
0 (Fatty Acids)
0 (Fatty Acids, Monounsaturated)
0 (Trans Fatty Acids)
تواريخ الأحداث: Date Created: 20130329 Date Completed: 20140113 Latest Revision: 20220408
رمز التحديث: 20231215
DOI: 10.1017/S0007114513000858
PMID: 23534456
قاعدة البيانات: MEDLINE
الوصف
تدمد:1475-2662
DOI:10.1017/S0007114513000858