دورية أكاديمية
Biphasic fusion of the murine posterior frontal suture.
| العنوان: | Biphasic fusion of the murine posterior frontal suture. |
|---|---|
| المؤلفون: | Hermann CD; Atlanta, Ga. From the Petit Institute for Bioengineering and Bioscience, the Wallace H. Coulter Department of Biomedical Engineering, and the Woodruff School of Mechanical Engineering, Georgia Institute of Technology; Emory University School of Medicine; and Children's Healthcare of Atlanta., Richards MA, Chang R, Olivares-Navarrete R, Williams JK, Guldberg RE, Vidakovic B, Schwartz Z, Boyan BD |
| المصدر: | Plastic and reconstructive surgery [Plast Reconstr Surg] 2013 Apr; Vol. 131 (4), pp. 727-740. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 1306050 Publication Model: Print Cited Medium: Internet ISSN: 1529-4242 (Electronic) Linking ISSN: 00321052 NLM ISO Abbreviation: Plast Reconstr Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: Baltimore : Williams & Wilkins, |
| مواضيع طبية MeSH: | Cranial Sutures/*growth & development , Frontal Bone/*growth & development, Age Factors ; Animals ; Animals, Newborn ; Gene Expression ; Male ; Mice ; Mice, Inbred C57BL ; Real-Time Polymerase Chain Reaction |
| مستخلص: | Background: Craniosynostosis is the premature fusion of cranial sutures early in development. Mice are commonly used to study the mechanisms driving both normal and pathologic cranial suture development. Despite their frequency of use as a model, the time course of bone formation and mineralization during fusion of mouse posterior frontal suture is not well defined. Methods: To address this, C57Bl/6J mice were euthanized at ages ranging from 6 to 107 days, and the posterior frontal sutures were imaged using micro-computed tomography. Scans were analyzed with an image-processing algorithm that was previously validated with serial histology to quantify both suture fusion and mineral content. The expression profile of genes associated with key developmental time points was examined using real-time polymerase chain reaction in both the bone and the dura. Results: Results demonstrate that the bones of the posterior frontal suture come together during days 10 to 20 and then increase in mineral content and volume between days 21 and 45. The onset of posterior frontal suture fusion was associated with an increase in cartilage-associated genes on day 12. Later mineralization of the suture was associated with an increase in mRNAs for osteoblast differentiation markers, bone morphogenetic proteins, and bone morphogenetic protein inhibitors. Conclusions: Complete analysis fusion posterior frontal suture shows that it occurs in a discontinuous biphasic manner. The first phase is from days 10 to 20 and involves production of cartilage. A second mineralization phase from days 21 to 45 was seen with both the imaging algorithm and changes in gene expression. |
| References: | Opperman LA. Cranial sutures as intramembranous bone growth sites. Dev Dyn. 2000;219:472–485. Vu HL, Panchal J, Parker EE, Levine NS, Francel P. The timing of physiologic closure of the metopic suture: A review of 159 patients using reconstructed 3D CT scans of the craniofacial region. J Craniofac Surg. 2001;12:527–532. Kwan MD, Wan DC, Wang Z, Gupta DM, Slater BJ, Longaker MT. Microarray analysis of the role of regional dura mater in cranial suture fate. Plast Reconstr Surg. 2008;122:389–399. Bradley JP, Levine JP, Blewett C, Krummel T, McCarthy JG, Longaker MT. Studies in cranial suture biology: In vitro cranial suture fusion. Cleft Palate Craniofac J. 1996;33:150–156. Bradley JP, Levine JP, Roth DA, McCarthy JG, Longaker MT. Studies in cranial suture biology: IV. Temporal sequence of posterior frontal cranial suture fusion in the mouse. Plast Reconstr Surg. 1996;98:1039–1045. Stadler JA III, Cortes W, Zhang LL, Hanger CC, Gosain AK. A reinvestigation of murine cranial suture biology: Microcomputed tomography versus histologic technique. Plast Reconstr Surg. 2006;118:626–634. Recinos RF, Hanger CC, Schaefer RB, Dawson CA, Gosain AK. Microfocal CT: A method for evaluating murine cranial sutures in situ. J Surg Res. 2004;116:322–329. Gosain AK, Cortes W, Chim H, Beck D. Application of micro-computed tomographic scanning to characterize patterns of murine cranial suture fusion. Plast Reconstr Surg. 2011;127:1847–1854. Hermann CD, Richards MA, Olivares-Navarrete R, et al.. Algorithm to assess cranial suture fusion with varying and discontinuous mineral density. Ann Biomed Eng. 2012;40:1597–1609. Sahar DE, Longaker MT, Quarto N. Sox9 neural crest determinant gene controls patterning and closure of the posterior frontal cranial suture. Dev Biol. 2005;280:344–361. Li R, Svenson KL, Donahue LR, Peters LL, Churchill GA. Relationships of dietary fat, body composition, and bone mineral density in inbred mouse strain panels. Physiol Genomics 2008;33:26–32. Opperman LA, Adab K, Gakunga PT. Transforming growth factor-beta 2 and TGF-beta 3 regulate fetal rat cranial suture morphogenesis by regulating rates of cell proliferation and apoptosis. Dev Dyn. 2000;219:237–247. Opperman LA, Chhabra A, Cho RW, Ogle RC. Cranial suture obliteration is induced by removal of transforming growth factor (TGF)-beta 3 activity and prevented by removal of TGF-beta 2 activity from fetal rat calvaria in vitro. J Craniofac Genet Dev Biol. 1999;19:164–173. Kawakami Y, Rodriguez-León J, Izpisúa Belmonte JC. The role of TGFbetas and Sox9 during limb chondrogenesis. Curr Opin Cell Biol. 2006;18:723–729. Pan Q, Yu Y, Chen Q, et al.. Sox9, a key transcription factor of bone morphogenetic protein-2-induced chondrogenesis, is activated through BMP pathway and a CCAAT box in the proximal promoter. J Cell Physiol. 2008;217:228–241. Schmid TM, Bonen DK, Luchene L, Linsenmayer TF. Late events in chondrocyte differentiation: Hypertrophy, type X collagen synthesis and matrix calcification. In Vivo 1991;5:533–540. Sahar DE, Behr B, Fong KD, Longaker MT, Quarto N. Unique modulation of cadherin expression pattern during posterior frontal cranial suture development and closure. Cells Tissues Organs 2010;191:401–413. Cho JY, Lee WB, Kim HJ, et al.. Bone-related gene profiles in developing calvaria. Gene 2006;372:71–81. Erickson DM, Harris SE, Dean DD, et al.. Recombinant bone morphogenetic protein (BMP)-2 regulates costochondral growth plate chondrocytes and induces expression of BMP-2 and BMP-4 in a cell maturation-dependent manner. J Orthop Res. 1997;15:371–380. Shu B, Zhang M, Xie R, et al.. BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. J Cell Sci. 2011;124:3428–3440. Hoffman LM, Garcha K, Karamboulas K, et al.. BMP action in skeletogenesis involves attenuation of retinoid signaling. J Cell Biol. 2006;174:101–113. Song HM, Sahar DE, Fong KD, et al.. In vitro murine posterior frontal suture fate is age-dependent: Implications for cranial suture biology. Plast Reconstr Surg. 2004;113:1192–1204. Zimmerman LB, De Jesús-Escobar JM, Harland RM. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 1996;86:599–606. Perry MJ, McDougall KE, Hou SC, Tobias JH. Impaired growth plate function in bmp-6 null mice. Bone 2008;42:216–225. Kusu N, Laurikkala J, Imanishi M, et al.. Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity. J Biol Chem. 2003;278:24113–24117. Dieudonné SC, Semeins CM, Goei SW, et al.. Opposite effects of osteogenic protein and transforming growth factor beta on chondrogenesis in cultured long bone rudiments. J Bone Miner Res. 1994;9:771–780. Nilsson O, Parker EA, Hegde A, Chau M, Barnes KM, Baron J. Gradients in bone morphogenetic protein-related gene expression across the growth plate. J Endocrinol. 2007;193:75–84. Levine JP, Bradley JP, Roth DA, McCarthy JG, Longaker MT. Studies in cranial suture biology: Regional dura mater determines overlying suture biology. Plast Reconstr Surg. 1998;101:1441–1447. |
| تواريخ الأحداث: | Date Created: 20130402 Date Completed: 20130520 Latest Revision: 20210106 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/PRS.0b013e3182827585 |
| PMID: | 23542246 |
| قاعدة البيانات: | MEDLINE |
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