دورية أكاديمية
Self-correction of chromosomal abnormalities in human preimplantation embryos and embryonic stem cells.
| العنوان: | Self-correction of chromosomal abnormalities in human preimplantation embryos and embryonic stem cells. |
|---|---|
| المؤلفون: | Bazrgar M; Department of Genetics, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran., Gourabi H, Valojerdi MR, Yazdi PE, Baharvand H |
| المصدر: | Stem cells and development [Stem Cells Dev] 2013 Sep 01; Vol. 22 (17), pp. 2449-56. Date of Electronic Publication: 2013 May 14. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101197107 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8534 (Electronic) Linking ISSN: 15473287 NLM ISO Abbreviation: Stem Cells Dev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Larchmont, NY : Mary Ann Liebert, Inc., c2004- |
| مواضيع طبية MeSH: | Aneuploidy*, Blastocyst/*cytology , Chromosome Disorders/*embryology , Chromosome Disorders/*genetics , Embryonic Stem Cells/*cytology, Chromosome Aberrations/embryology ; DNA Copy Number Variations ; Female ; Humans ; Mosaicism/embryology ; Pregnancy ; Preimplantation Diagnosis |
| مستخلص: | Aneuploidy is commonly seen in human preimplantation embryos, most particularly at the cleavage stage because of genome activation by third cell division. Aneuploid embryos have been used for the derivation of normal embryonic stem cell (ESC) lines and developmental modeling. This review addresses aneuploidies in human preimplantation embryos and human ESCs and the potential of self-correction of these aberrations. Diploid-aneuploid mosaicism is the most frequent abnormality observed; hence, embryos selected by preimplantation genetic diagnosis at the cleavage or blastocyst stage could be partly abnormal. Differentiation is known as the barrier for eliminating mosaic embryos by death and/or decreased division of abnormal cells. However, some mosaicisms, such as copy number variations could be compatible with live birth. Several reasons have been proposed for self-correction of aneuploidies during later stages of development, including primary misdiagnosis, allocation of the aneuploidy in the trophectoderm, cell growth advantage of diploid cells in mosaic embryos, lagging of aneuploid cell division, extrusion or duplication of an aneuploid chromosome, and the abundance of DNA repair gene products. Although more studies are needed to understand the mechanisms of self-correction as a rare phenomenon, most likely, it is related to overcoming mosaicism. |
| تواريخ الأحداث: | Date Created: 20130406 Date Completed: 20140331 Latest Revision: 20220316 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1089/scd.2013.0053 |
| PMID: | 23557100 |
| قاعدة البيانات: | MEDLINE |
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