دورية أكاديمية
Diffusion tensor imaging (DTI) in the detection of white matter lesions in patients with mild cognitive impairment (MCI).
| العنوان: | Diffusion tensor imaging (DTI) in the detection of white matter lesions in patients with mild cognitive impairment (MCI). |
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| المؤلفون: | Sali D, Verganelakis DA, Gotsis E, Toulas P, Papatriantafillou J, Karageorgiou C, Thomaides T, Kapsalaki EZ, Hadjigeorgiou G, Papadimitriou A |
| المصدر: | Acta neurologica Belgica [Acta Neurol Belg] 2013 Dec; Vol. 113 (4), pp. 441-51. Date of Electronic Publication: 2013 Apr 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Italy NLM ID: 0247035 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2240-2993 (Electronic) Linking ISSN: 03009009 NLM ISO Abbreviation: Acta Neurol Belg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2012- : Milan : Springer Original Publication: 1970-2011: Bruxelles : Acta Medica Belgica, |
| مواضيع طبية MeSH: | Brain/*pathology , Cognitive Dysfunction/*diagnosis , Nerve Fibers, Myelinated/*pathology, Adult ; Aged ; Cognitive Dysfunction/psychology ; Diffusion Tensor Imaging ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests |
| مستخلص: | Mild cognitive impairment (MCI) is recognized as a precursor to dementia. The amnestic MCI progresses usually to Alzheimer disease. Amnestic MCI multiple domain (md-MCI) seems to progress more rapidly than amnestic MCI single domain (a-MCI). In an attempt to identify patients at risk, we examined white matter changes in MCI subtypes using diffusion tensor imaging (DTI). We also tried to correlate DTI findings to neuropsychological tests. Forty-four amnestic single domain (a-MCI) patients, 19 amnestic multi domain (md-MCI), and 25 cognitively normal (NC) controls were included in the present study. All participants were assessed clinically using a battery of cognitive tests. DTI was performed to measure fractional anisotropy (FA) and apparent diffusion coefficient (ADC). Areas studied were corpus callosum, posterior cingulum (PC), anterior cingulum (AC), and superior longitudinal fasciculus (SLF). ADC and FA of the above areas were related to the scores of certain neuropsychological tests that evaluate visual and verbal memory. No difference in DTI measurements was found between the two MCI subtypes. ADC in MCI cases was increased in comparison with NC in the genu, PC, right SLF, and left AC. FA was spared. Verbal memory was related to ADC of the genu, PC, right AC and right SLF, and to FA of the left SLF. Visual memory was related to ADC of the genu, PC, right AC, and SLF. The strongest correlation found was between the visual memory and the ADC of the right PC (Spearman ρ = 0.45, p < 0.001). DTI revealed that ADC was increased in certain brain areas in MCI patients. No difference in DTI measurements was found between the two MCI subtypes. DTI indices correlate with cognitive performance. |
| التعليقات: | Erratum in: Acta Neurol Belg. 2013 Sep;113(3):369. Dimitra, Sali [corrected to Sali, Dimitra]. |
| تواريخ الأحداث: | Date Created: 20130430 Date Completed: 20140811 Latest Revision: 20161128 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s13760-013-0197-3 |
| PMID: | 23625776 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2240-2993 |
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| DOI: | 10.1007/s13760-013-0197-3 |