دورية أكاديمية
Luminescent cell-penetrating pentadecanuclear lanthanide clusters.
| العنوان: | Luminescent cell-penetrating pentadecanuclear lanthanide clusters. |
|---|---|
| المؤلفون: | Thielemann DT; Institute of Inorganic Chemistry, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany., Wagner AT, Rösch E, Kölmel DK, Heck JG, Rudat B, Neumaier M, Feldmann C, Schepers U, Bräse S, Roesky PW |
| المصدر: | Journal of the American Chemical Society [J Am Chem Soc] 2013 May 22; Vol. 135 (20), pp. 7454-7. Date of Electronic Publication: 2013 May 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : American Chemical Society Original Publication: Easton, Pa. [etc.] |
| مواضيع طبية MeSH: | Luminescence*, Lanthanoid Series Elements/*chemistry , Organometallic Compounds/*chemistry, Crystallography, X-Ray ; HeLa Cells ; Humans ; Models, Molecular ; Molecular Structure |
| مستخلص: | A novel pentadecanuclear lanthanide hydroxy cluster [{Ln15(μ3-OH)20(PepCO2)10(DBM)10Cl}Cl4] (Ln = Eu (1), Tb (2)) featuring the first example with peptoids as supporting ligands was prepared and fully characterized. The solid-state structures of 1 and 2 were established via single-crystal X-ray crystallography. ESI-MS experiments revealed the retention of the cluster core in solution. Although OH groups are present, 1 showed intense red fluorescence with 11(1)% absolute quantum yield, whereas the emission intensity and the quantum yield of 2 were significantly weaker. In vitro investigations on 1 and 2 with HeLa tumor cells revealed an accumulation of the clusters in the endosomal-lyosomal system, as confirmed by confocal microscopy in the TRLLM mode. The cytotoxicity of 1 and 2 toward the HeLa cells is moderate. |
| المشرفين على المادة: | 0 (Lanthanoid Series Elements) 0 (Organometallic Compounds) |
| تواريخ الأحداث: | Date Created: 20130509 Date Completed: 20131224 Latest Revision: 20130522 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1021/ja403539t |
| PMID: | 23650953 |
| قاعدة البيانات: | MEDLINE |
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