دورية أكاديمية
Inflammatory myopathy as the initial presentation of cryoglobulinaemic vasculitis.
| العنوان: | Inflammatory myopathy as the initial presentation of cryoglobulinaemic vasculitis. |
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| المؤلفون: | Rodríguez-Pérez N; Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico., Rodríguez-Navedo Y, Font YM, Vilá LM |
| المصدر: | BMJ case reports [BMJ Case Rep] 2013 Jun 03; Vol. 2013. Date of Electronic Publication: 2013 Jun 03. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 101526291 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-790X (Electronic) Linking ISSN: 1757790X NLM ISO Abbreviation: BMJ Case Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BMJ Pub. Group |
| مواضيع طبية MeSH: | Cryoglobulinemia/*diagnosis , Myositis/*diagnosis , Vasculitis/*diagnosis, Adult ; Cryoglobulinemia/drug therapy ; Cyclophosphamide/administration & dosage ; Cyclophosphamide/therapeutic use ; Female ; Humans ; Methylprednisolone/administration & dosage ; Methylprednisolone/therapeutic use ; Myositis/drug therapy ; Prednisone/administration & dosage ; Prednisone/therapeutic use ; Treatment Outcome ; Vasculitis/drug therapy |
| مستخلص: | Cryoglobulinaemic vasculitis is characterised by immunoglobulin deposition at low temperatures. The most common manifestations are cutaneous involvement, arthralgias, Raynaud's phenomenon, peripheral neuropathy and renal disease. Myopathy is unusual and only a few cases have been reported. Here, we present a 31-year-old woman who developed progressive muscle weakness involving upper and lower extremities, dysphagia, paraesthesias and palpable purpura. Diagnostic studies revealed elevated creatine kinase, diffuse myopathic and sensorimotor axonal neuropathy on electromyography and nerve conduction studies, and inflammatory myopathy on muscle biospsy. Cryoglobulin levels were elevated on two occasions. She responded favourably to cyclophosphamide and high-dose corticosteroids. Cyclophosphamide was continued for 1 year followed by methotrexate. Prednisone was gradually tapered and discontinued 1 year later. She remained in clinical remission after 4 years of follow-up. This case suggests that cryoglobulinaemia should be considered in the differential diagnosis of a patient presenting with inflammatory myopathy. |
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| المشرفين على المادة: | 8N3DW7272P (Cyclophosphamide) VB0R961HZT (Prednisone) X4W7ZR7023 (Methylprednisolone) |
| تواريخ الأحداث: | Date Created: 20130606 Date Completed: 20140916 Latest Revision: 20211021 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC3702929 |
| DOI: | 10.1136/bcr-2013-010117 |
| PMID: | 23737595 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1757-790X |
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| DOI: | 10.1136/bcr-2013-010117 |