دورية أكاديمية
Bach2 maintains T cells in a naive state by suppressing effector memory-related genes.
| العنوان: | Bach2 maintains T cells in a naive state by suppressing effector memory-related genes. |
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| المؤلفون: | Tsukumo S; Laboratory of Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan., Unno M, Muto A, Takeuchi A, Kometani K, Kurosaki T, Igarashi K, Saito T |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2013 Jun 25; Vol. 110 (26), pp. 10735-40. Date of Electronic Publication: 2013 Jun 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Basic-Leucine Zipper Transcription Factors/*immunology , Immunologic Memory/*genetics , Suppression, Genetic/*immunology , T-Lymphocyte Subsets/*immunology, Animals ; Basic-Leucine Zipper Transcription Factors/deficiency ; Basic-Leucine Zipper Transcription Factors/genetics ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Cytokines/antagonists & inhibitors ; Cytokines/biosynthesis ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; T-Lymphocyte Subsets/cytology ; Th2 Cells/cytology ; Th2 Cells/immunology ; Th2 Cells/metabolism |
| مستخلص: | The transcriptional repressor BTB and CNC homology 2 (Bach2) is thought to be mainly expressed in B cells with specific functions such as class switch recombination and somatic hypermutation, but its function in T cells is not known. We found equal Bach2 expression in T cells and analyzed its function using Bach2-deficient (-/-) mice. Although T-cell development was normal, numbers of peripheral naive T cells were decreased, which rapidly produced Th2 cytokines after TCR stimulation. Bach2(-/-) naive T cells highly expressed genes related to effector-memory T cells such as CCR4, ST-2 and Blimp-1. Enhanced expression of these genes induced Bach2(-/-) naive T cells to migrate toward CCR4-ligand and respond to IL33. Forced expression of Bach2 restored the expression of these genes. Using Chromatin Immunoprecipitation (ChIP)-seq analysis, we identified S100 calcium binding protein a, Heme oxigenase 1, and prolyl hydroxylase 3 as Bach2 direct target genes, which are highly expressed in effector-memory T cells. These findings indicate that Bach2 suppresses effector memory-related genes to maintain the naive T-cell state and regulates generation of effector-memory T cells. |
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| فهرسة مساهمة: | Keywords: CNC family; innate-like lymphocytes; transcription factor |
| المشرفين على المادة: | 0 (Bach2 protein, mouse) 0 (Basic-Leucine Zipper Transcription Factors) 0 (Cytokines) |
| تواريخ الأحداث: | Date Created: 20130612 Date Completed: 20130906 Latest Revision: 20220316 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC3696756 |
| DOI: | 10.1073/pnas.1306691110 |
| PMID: | 23754397 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1091-6490 |
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| DOI: | 10.1073/pnas.1306691110 |