دورية أكاديمية
أعرض في EDS

Schistosomiasis control using piplartine against Biomphalaria glabrata at different developmental stages.

التفاصيل البيبلوغرافية
العنوان: Schistosomiasis control using piplartine against Biomphalaria glabrata at different developmental stages.
المؤلفون: Rapado LN; Laboratório de Parasitologia, Instituto Butantan, São Paulo, Brazil., Pinheiro Ade S, Lopes PO, Fokoue HH, Scotti MT, Marques JV, Ohlweiler FP, Borrely SI, Pereira CA, Kato MJ, Nakano E, Yamaguchi LF
المصدر: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2013 Jun 06; Vol. 7 (6), pp. e2251. Date of Electronic Publication: 2013 Jun 06 (Print Publication: 2013).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Antiparasitic Agents/*pharmacology , Biomphalaria/*drug effects , Biomphalaria/*parasitology , Piper/*chemistry , Piperidones/*pharmacology , Plant Extracts/*pharmacology, Animals ; Antiparasitic Agents/isolation & purification ; Biological Assay ; Magnetic Resonance Spectroscopy ; Piperidones/isolation & purification ; Plant Extracts/isolation & purification ; Spectrometry, Mass, Electrospray Ionization ; Survival Analysis
مستخلص: Background: Schistosomiasis is one of the most significant diseases in tropical countries and affects almost 200 million people worldwide. The application of molluscicides to eliminate the parasite's intermediate host, Biomphalaria glabrata, from infected water supplies is one strategy currently being used to control the disease. Previous studies have shown a potent molluscicidal activity of crude extracts from Piper species, with extracts from Piper tuberculatum being among the most active.
Methods and Findings: The molluscicidal activity of P. tuberculatum was monitored on methanolic extracts from different organs (roots, leaves, fruit and stems). The compounds responsible for the molluscicidal activity were identified using (1)H NMR and ESIMS data and multivariate analyses, including principal component analysis and partial least squares. These results indicated that the high molluscicidal activity displayed by root extracts (LC50 20.28 µg/ml) was due to the presence of piplartine, a well-known biologically-active amide. Piplartine was isolated from P. tuberculatum root extracts, and the molluscicidal activity of this compound on adults and embryos of B. glabrata was determined. The compound displayed potent activity against all developmental stages of B. glabrata. Next, the environmental toxicity of piplartine was evaluated using the microcrustacean Daphnia similis (LC50 7.32 µg/ml) and the fish Danio rerio (1.69 µg/ml). The toxicity to these organisms was less compared with the toxicity of niclosamide, a commercial molluscicide.
Conclusions: The development of a new, natural molluscicide is highly desirable, particularly because the commercially available molluscicide niclosamide is highly toxic to some organisms in the environment (LC50 0.25 µg/ml to D. similis and 0.12 µg/ml to D. rerio). Thus, piplartine is a potential candidate for a natural molluscicide that has been extracted from a tropical plant species and showed less toxic to environment.
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المشرفين على المادة: 0 (Antiparasitic Agents)
0 (Piperidones)
0 (Plant Extracts)
SGD66V4SVJ (piperlongumine)
تواريخ الأحداث: Date Created: 20130612 Date Completed: 20131216 Latest Revision: 20231213
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3675008
DOI: 10.1371/journal.pntd.0002251
PMID: 23755312
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-2735
DOI:10.1371/journal.pntd.0002251