دورية أكاديمية
Rise and fall of HCV-related hepatocellular carcinoma in Italy: a long-term survey from the ITA.LI.CA centres.
| العنوان: | Rise and fall of HCV-related hepatocellular carcinoma in Italy: a long-term survey from the ITA.LI.CA centres. |
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| المؤلفون: | Cazzagon N; Dipartimento di Scienze Chirurgiche Oncologiche e Gastroenterologiche 'P.G. Cevese', Università degli Studi di Padova, Padova, Italia., Trevisani F, Maddalo G, Giacomin A, Vanin V, Pozzan C, Poggio PD, Rapaccini G, Nolfo AM, Benvegnù L, Zoli M, Borzio F, Giannini EG, Caturelli E, Chiaramonte M, Foschi FG, Cabibbo G, Felder M, Ciccarese F, Missale G, Baroni GS, Morisco F, Pecorelli A, Farinati F |
| مؤلفون مشاركون: | Italian Liver Cancer (ITA.LI.CA) Group |
| المصدر: | Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2013 Oct; Vol. 33 (9), pp. 1420-7. Date of Electronic Publication: 2013 Jun 12. |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101160857 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-3231 (Electronic) Linking ISSN: 14783223 NLM ISO Abbreviation: Liver Int Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Malden, MA : Wiley-Blackwell Original Publication: Oxford, UK : Blackwell Munksgaard, c2003- |
| مواضيع طبية MeSH: | Carcinoma, Hepatocellular/*epidemiology , Hepatitis C/*complications , Hepatitis C/*epidemiology , Liver Neoplasms/*epidemiology, Age Factors ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/virology ; Female ; Humans ; Incidence ; Italy/epidemiology ; Liver Neoplasms/etiology ; Liver Neoplasms/pathology ; Liver Neoplasms/virology ; Male ; Prevalence ; Retrospective Studies ; Sex Factors ; Survival Analysis |
| مستخلص: | Background & Aims: Hepatitis C virus (HCV) is the leading aetiological factor of HCC in the western world where, overall, its incidence is increasing, despite data suggesting an initial drop in some areas. The aim of this study was to evaluate epidemiology, clinical features and survival of HCV-related HCC (HCV-HCC) in a wide time range in Italy. Methods: Multicentre retrospective study including 3695 patients prospectively recruited by the ITA.LI.CA group. Patients were classified into three subgroups according to aetiology (Group A[GA], pure HCV; Group B[GB], HCV + cofactors; and Group C[GC], non-HCV) and in 5 time cohorts (5 years each), according to the year of diagnosis. Age, gender, Child-Pugh score, modality of diagnosis, stage, presence of thrombosis/metastases, type of treatment and survival were analysed. Results: A total of 1801 GA patients, 445 GB and 1333 GC were recruited. The number of GA patients peaked in the 1996-2000, gradually dropping thereafter (P < 0.0001), as observed for GB (P < 0.0001). Age at diagnosis increased (P < 0.0001), while percentage of patients diagnosed during surveillance and stage improved only in GA (P = 0.02 and P = 0.003 respectively). The survival significantly increased over time particularly in GA (median 37 months) and was longer in GA than in GB and GC (P < 0.0001). Conclusions: The prevalence of HCC-HCV is decreasing in Italy since 2001. HCV-HCC patients are older, more frequently diagnosed under surveillance and in an earlier stage. HCC survival improved in the last 15 years and is significantly higher in patients with HCV-HCC. We therefore expect a further drop in both incidence and mortality for HCV-HCC in the years to come. (© 2013 John Wiley & Sons A/S.) |
| فهرسة مساهمة: | Investigator: M Bernardi; D Buccione; P Caraceni; A Di Micoli; M Domenicali; A Gramenzi; G Fatti; M Frigerio; FM Cappa; V Santi; D Magalotti; M Ravaioli; E Giampalma; R Golfieri; M Di Marco; E Vavassori; L Gilardoni; M Mattiello; A Alberti; A Gatta; M Gios; P Roselli; G Ghittoni; G Bodini; M Corbo; S Marenco Keywords: cirrhosis; hepatitis C; hepatocellular carcinoma |
| تواريخ الأحداث: | Date Created: 20130614 Date Completed: 20140331 Latest Revision: 20130909 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/liv.12208 |
| PMID: | 23758775 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1478-3231 |
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| DOI: | 10.1111/liv.12208 |