دورية أكاديمية
أعرض في EDS

Preventing the onset of major depression based on the level and profile of risk of primary care attendees: protocol of a cluster randomised trial (the predictD-CCRT study).

التفاصيل البيبلوغرافية
العنوان: Preventing the onset of major depression based on the level and profile of risk of primary care attendees: protocol of a cluster randomised trial (the predictD-CCRT study).
المؤلفون: Bellón JÁ, Conejo-Cerón S, Moreno-Peral P, King M, Nazareth I, Martín-Pérez C, Fernández-Alonso C, Ballesta-Rodríguez MI, Fernández A, Aiarzaguena JM, Montón-Franco C, Ibanez-Casas I, Rodríguez-Sánchez E, Rodríguez-Bayón A, Serrano-Blanco A, Gómez MC, LaFuente P, Del Mar Muñoz-García M, Mínguez-Gonzalo P, Araujo L, Palao D, Espinosa-Cifuentes M, Zubiaga F, Navas-Campaña D, Mendive J, Aranda-Regules JM, Rodriguez-Morejón A, Salvador-Carulla L, de Dios Luna J
المصدر: BMC psychiatry [BMC Psychiatry] 2013 Jun 19; Vol. 13, pp. 171. Date of Electronic Publication: 2013 Jun 19.
نوع المنشور: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968559 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-244X (Electronic) Linking ISSN: 1471244X NLM ISO Abbreviation: BMC Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Quality of Life*, Depressive Disorder, Major/*prevention & control , Primary Health Care/*methods, Adult ; Clinical Protocols ; Cost-Benefit Analysis ; Depressive Disorder, Major/economics ; Humans ; Primary Health Care/economics ; Research Design ; Risk ; Spain
مستخلص: Background: The 'predictD algorithm' provides an estimate of the level and profile of risk of the onset of major depression in primary care attendees. This gives us the opportunity to develop interventions to prevent depression in a personalized way. We aim to evaluate the effectiveness, cost-effectiveness and cost-utility of a new intervention, personalized and implemented by family physicians (FPs), to prevent the onset of episodes of major depression.
Methods/design: This is a multicenter randomized controlled trial (RCT), with cluster assignment by health center and two parallel arms. Two interventions will be applied by FPs, usual care versus the new intervention predictD-CCRT. The latter has four components: a training workshop for FPs; communicating the level and profile of risk of depression; building up a tailored bio-psycho-family-social intervention by FPs to prevent depression; offering a booklet to prevent depression; and activating and empowering patients. We will recruit a systematic random sample of 3286 non-depressed adult patients (1643 in each trial arm), nested in 140 FPs and 70 health centers from 7 Spanish cities. All patients will be evaluated at baseline, 6, 12 and 18 months. The level and profile of risk of depression will be communicated to patients by the FPs in the intervention practices at baseline, 6 and 12 months. Our primary outcome will be the cumulative incidence of major depression (measured by CIDI each 6 months) over 18 months of follow-up. Secondary outcomes will be health-related quality of life (SF-12 and EuroQol), and measurements of cost-effectiveness and cost-utility. The inferences will be made at patient level. We shall undertake an intention-to-treat effectiveness analysis and will handle missing data using multiple imputations. We will perform multi-level logistic regressions and will adjust for the probability of the onset of major depression at 12 months measured at baseline as well as for unbalanced variables if appropriate. The economic evaluation will be approached from two perspectives, societal and health system.
Discussion: To our knowledge, this will be the first RCT of universal primary prevention for depression in adults and the first to test a personalized intervention implemented by FPs. We discuss possible biases as well as other limitations.
Trial Registration: ClinicalTrials.gov identifier: NCT01151982.
References: Am J Geriatr Psychiatry. 2008 Jun;16(6):435-43. (PMID: 18515687)
Ann Oncol. 2009 May;20(5):928-34. (PMID: 19126633)
Med J Aust. 2007 Mar 19;186(6):305-8. (PMID: 17371212)
Cochrane Database Syst Rev. 2005 Apr 18;(2):CD004363. (PMID: 15846711)
BMC Fam Pract. 2005 Nov 04;6:45. (PMID: 16271136)
Acta Psychiatr Scand. 2007 Jun;115(6):434-41. (PMID: 17498154)
PLoS Med. 2006 Nov;3(11):e442. (PMID: 17132052)
Clin Psychol Rev. 2009 Jul;29(5):449-58. (PMID: 19450912)
Int J Psychiatry Med. 2004;34(1):21-35. (PMID: 15242139)
BMJ. 2001 Oct 27;323(7319):948-9. (PMID: 11679372)
Ann Intern Med. 2008 Feb 19;148(4):295-309. (PMID: 18283207)
BMC Public Health. 2006 Jan 12;6:6. (PMID: 16409633)
J Affect Disord. 2011 Jan;128(1-2):10-23. (PMID: 20346517)
Arch Gen Psychiatry. 2008 Dec;65(12):1368-76. (PMID: 19047523)
Stat Med. 2011 Feb 20;30(4):377-99. (PMID: 21225900)
J Affect Disord. 2007 Jan;97(1-3):219-28. (PMID: 16860874)
Cochrane Database Syst Rev. 2011 Dec 07;(12):CD003380. (PMID: 22161377)
J Consult Clin Psychol. 2005 Feb;73(1):160-7. (PMID: 15709843)
J Affect Disord. 2011 Jul;132(1-2):130-8. (PMID: 21402411)
EPMA J. 2012 Nov 01;3(1):14. (PMID: 23116135)
Br J Psychiatry. 2004 Nov;185:416-21. (PMID: 15516551)
Aten Primaria. 2012 Jun;44 Suppl 1:52-6. (PMID: 23399507)
J Epidemiol Community Health. 2010 Oct;64(10):874-84. (PMID: 19759057)
Cochrane Database Syst Rev. 2013 Feb 28;(2):CD001134. (PMID: 23450532)
JAMA. 1999 Nov 10;282(18):1737-44. (PMID: 10568646)
Actas Esp Psiquiatr. 1999 Nov-Dec;27(6):375-83. (PMID: 10611561)
Cochrane Database Syst Rev. 2008 Jul 16;(3):CD003689. (PMID: 18646094)
Am J Psychiatry. 2005 Jun;162(6):1149-57. (PMID: 15930064)
Am J Community Psychol. 1995 Apr;23(2):199-222. (PMID: 7572830)
Epidemiology. 2004 Sep;15(5):615-25. (PMID: 15308962)
Aten Primaria. 1998 Jan;21(1):14-22. (PMID: 9557352)
BMJ. 2013 Jan 21;346:e8668. (PMID: 23338004)
Br J Gen Pract. 2011 May;61(586):350. (PMID: 21619768)
Annu Rev Clin Psychol. 2011;7:169-201. (PMID: 21443447)
Acta Psychiatr Scand Suppl. 2004;(420):21-7. (PMID: 15128384)
Br J Psychiatry. 2003 Jan;182:71-6. (PMID: 12509322)
Br J Psychiatry. 2004 May;184:386-92. (PMID: 15123501)
Am J Psychiatry. 2008 Oct;165(10):1272-80. (PMID: 18765483)
BMJ. 2003 Nov 15;327(7424):1144-6. (PMID: 14615341)
Dialogues Clin Neurosci. 2009;11(4):447-54. (PMID: 20135902)
Qual Life Res. 1998 May;7(4):311-22. (PMID: 9610215)
Psychol Med. 2011 Apr;41(4):739-48. (PMID: 20716383)
JAMA. 2003 Jun 18;289(23):3135-44. (PMID: 12813119)
Br J Psychiatry. 2008 May;192(5):362-7. (PMID: 18450661)
Med Clin (Barc). 1999;112 Suppl 1:79-85. (PMID: 10618804)
Am J Epidemiol. 2012 Feb 1;175(3):210-7. (PMID: 22262640)
Psychosomatics. 2009 May-Jun;50(3):227-33. (PMID: 19567761)
Ann Intern Med. 2007 Jun 19;146(12):848-56. (PMID: 17577004)
Am J Geriatr Psychiatry. 2008 Nov;16(11):893-904. (PMID: 18978250)
Br J Gen Pract. 1996 Feb;46(403):105-7. (PMID: 8855018)
Br J Psychiatry. 2005 Aug;187:106-8. (PMID: 16055820)
Annu Rev Clin Psychol. 2010;6:181-212. (PMID: 20192789)
BMC Public Health. 2008 Jul 25;8:256. (PMID: 18657275)
Diabet Med. 2010 Nov;27(11):1295-301. (PMID: 20950389)
BMJ. 2009 Jun 29;338:b2393. (PMID: 19564179)
Aust N Z J Psychiatry. 2011 Jan;45(1):36-44. (PMID: 21073354)
Br J Psychiatry. 2010 Apr;196(4):319-25. (PMID: 20357310)
J Affect Disord. 2007 Feb;98(1-2):29-43. (PMID: 16952399)
BMJ. 2008 Apr 19;336(7649):876-80. (PMID: 18364360)
Arch Gen Psychiatry. 2001 Dec;58(12):1127-34. (PMID: 11735841)
Prev Sci. 2007 Sep;8(3):206-13. (PMID: 17549635)
Arch Gen Psychiatry. 1988 Dec;45(12):1069-77. (PMID: 2848472)
J Clin Epidemiol. 1998 Nov;51(11):1171-8. (PMID: 9817135)
Arch Gen Psychiatry. 2009 Mar;66(3):297-304. (PMID: 19255379)
BMJ. 2005 Jul 2;331(7507):15. (PMID: 15994688)
Depress Anxiety. 2009;26(12):1062-5. (PMID: 19957277)
Am J Psychiatry. 1995 Sep;152(9):1329-35. (PMID: 7653689)
J Adolesc. 2010 Jun;33(3):429-38. (PMID: 19647310)
BMJ. 2003 Sep 27;327(7417):741-4. (PMID: 14512488)
J Child Psychol Psychiatry. 2005 Sep;46(9):982-94. (PMID: 16109001)
Acta Psiquiatr Psicol Am Lat. 1991 Sep;37(3):191-204. (PMID: 1811404)
Health Policy. 1990 Dec;16(3):199-208. (PMID: 10109801)
Br J Psychiatry. 2006 Apr;188:330-6. (PMID: 16582059)
Pediatrics. 2003 Aug;112(2):e119-31. (PMID: 12897317)
J Affect Disord. 2002 Dec;72(3):227-36. (PMID: 12450639)
Arch Gen Psychiatry. 2007 Aug;64(8):886-92. (PMID: 17679633)
J Consult Clin Psychol. 2009 Jun;77(3):486-503. (PMID: 19485590)
J Ment Health Policy Econ. 2006 Jun;9(2):87-98. (PMID: 17007486)
J Public Health Med. 1997 Jun;19(2):179-86. (PMID: 9243433)
Aust N Z J Psychiatry. 2006 Jan;40(1):36-41. (PMID: 16403035)
Br J Psychiatry. 2004 May;184:393-403. (PMID: 15123502)
Fam Med. 1986 May-Jun;18(3):153-6. (PMID: 3582830)
Aten Primaria. 2001 Oct 15;28(6):425-30. (PMID: 11602124)
J Affect Disord. 2008 Mar;106(3):257-63. (PMID: 17673299)
Fam Pract. 2005 Dec;22(6):663-9. (PMID: 16055464)
Psychol Med. 2011 Oct;41(10):2075-88. (PMID: 21466749)
JAMA. 2003 Jun 18;289(23):3095-105. (PMID: 12813115)
سلسلة جزيئية: ClinicalTrials.gov NCT01151982
تواريخ الأحداث: Date Created: 20130621 Date Completed: 20150106 Latest Revision: 20211021
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3698147
DOI: 10.1186/1471-244X-13-171
PMID: 23782553
قاعدة البيانات: MEDLINE
كن أول من يترك تعليقا!
يجب تسجيل دخولك أولا