دورية أكاديمية
Effects of renal denervation with a standard irrigated cardiac ablation catheter on blood pressure and renal function in patients with chronic kidney disease and resistant hypertension.
| العنوان: | Effects of renal denervation with a standard irrigated cardiac ablation catheter on blood pressure and renal function in patients with chronic kidney disease and resistant hypertension. |
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| المؤلفون: | Kiuchi MG; Renal Division, Department of Medicine, Universidade Federal Fluminense, Niterói, RJ, Brazil., Maia GL, de Queiroz Carreira MA, Kiuchi T, Chen S, Andrea BR, Graciano ML, Lugon JR |
| المصدر: | European heart journal [Eur Heart J] 2013 Jul; Vol. 34 (28), pp. 2114-21. Date of Electronic Publication: 2013 Jun 20. |
| نوع المنشور: | Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 8006263 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-9645 (Electronic) Linking ISSN: 0195668X NLM ISO Abbreviation: Eur Heart J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : Oxford : Oxford University Press Original Publication: London, Saunders [etc.] |
| مواضيع طبية MeSH: | Catheter Ablation/*methods , Hypertension/*surgery , Renal Insufficiency, Chronic/*complications , Sympathectomy/*methods, Albuminuria/diagnosis ; Albuminuria/etiology ; Analysis of Variance ; Antihypertensive Agents/therapeutic use ; Blood Pressure/physiology ; Chronic Disease ; Creatinine/metabolism ; Drug Resistance ; Female ; Glomerular Filtration Rate/physiology ; Humans ; Hypertension/physiopathology ; Male ; Middle Aged ; Prospective Studies ; Renal Insufficiency, Chronic/physiopathology ; Treatment Outcome |
| مستخلص: | Aims: Evaluation of the safety and efficacy of renal denervation with a standard irrigated cardiac ablation catheter (SICAC) in chronic kidney disease (CKD) patients with refractory hypertension. Methods and Results: Twenty-four patients were included and treated with a SICAC. Denervation was performed by a single operator following the standard technique. Patients included with CKD were on stages 2 (n = 16), 3 (n = 4), and 4 (n = 4). Data were obtained at baseline and monthly until 180th day of follow-up. Baseline values of blood pressure (mean ± SD) were 186 ± 19 mmHg/108 ± 13 mmHg in the office, and 151 ± 18 mmHg/92 ± 11 mmHg by 24 h ambulatory blood pressure monitoring (ABPM). Office blood pressure values at 180th day after the procedure were 135 ± 13 mmHg/88 ± 7 mmHg (P < 0.0001, for both comparisons). The mean ABPM decreased to 132 ± 15 mmHg/85 ± 11 mmHg at the 180th day after the procedure (P < 0.0001 for systolic and P = 0.0015 for diastolic). Estimated glomerular filtration (mean ± SD) increased from baseline (64.4 ± 23.9 mL/min/1.73 m(2)) to the 180th day (85.4 ± 34.9 mL/min/1.73 m(2), P < 0.0001) of follow-up. The median urine albumin:creatinine ratio decreased from baseline (48.5, IQR: 35.8-157.2 mg/g) to the 180th day after ablation (ACR = 15.7, IQR: 10.3-34.2 mg/g, P = 0.0017). No major complications were seen. Conclusion: The procedure using SICAC seemed to be feasible, effective, and safe resulting in a better control of BP, a short-term increase in estimated glomerular filtration rate, and reduced albuminuria. Although encouraging, our data are preliminary and need to be validated in the long term. |
| فهرسة مساهمة: | Keywords: Blood pressure reduction; Chronic kidney disease; Hypertension; Improvement of renal function; Renal denervation |
| المشرفين على المادة: | 0 (Antihypertensive Agents) AYI8EX34EU (Creatinine) |
| تواريخ الأحداث: | Date Created: 20130622 Date Completed: 20140310 Latest Revision: 20220410 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1093/eurheartj/eht200 |
| PMID: | 23786861 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1522-9645 |
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| DOI: | 10.1093/eurheartj/eht200 |