دورية أكاديمية
أعرض في EDS

HLA and MICA polymorphism in Polynesians and New Zealand Maori: implications for ancestry and health.

التفاصيل البيبلوغرافية
العنوان: HLA and MICA polymorphism in Polynesians and New Zealand Maori: implications for ancestry and health.
المؤلفون: Edinur HA; School of Biological Sciences, Victoria University of Wellington, New Zealand., Dunn PP, Hammond L, Selwyn C, Brescia P, Askar M, Reville P, Velickovic ZM, Lea RA, Chambers GK
المصدر: Human immunology [Hum Immunol] 2013 Sep; Vol. 74 (9), pp. 1119-29. Date of Electronic Publication: 2013 Jun 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Country of Publication: United States NLM ID: 8010936 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1166 (Electronic) Linking ISSN: 01988859 NLM ISO Abbreviation: Hum Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [New York] Elsevier/North-Holland.
مواضيع طبية MeSH: HLA Antigens/*genetics , Histocompatibility Antigens Class I/*genetics , Native Hawaiian or Other Pacific Islander/*genetics, Alleles ; Gene Frequency ; Genotype ; Health ; Histocompatibility Testing ; Humans ; Linkage Disequilibrium ; New Zealand ; Polymorphism, Genetic ; Polynesia ; Recombination, Genetic
مستخلص: Data from HLA typing studies have made significant contributions to genetic theories about the Austronesian diaspora and the health of descendant populations. To help further unravel pattern and process elements, we have typed HLA and MICA loci at high resolution in DNA samples from well defined groups of Maori and Polynesian individuals. Our results show a restricted set of HLA class I alleles compared with other well characterised populations. In contrast, the class II HLA-DRB1 locus seems to be diverse in Maori and Polynesians and both groups show high frequencies of HLA-DRB1(∗)04:03, -DRB1(∗)08:03, -DRB1(∗)09:01 and -DRB1(∗)12:01. Our survey also provides the first ever MICA datasets for Polynesians and reveal unusual distributions and associations with the HLA-B locus. Overall, our data provide further support for a hybrid origin for Maori and Polynesians. One novel feature of our study is the finding that the gene sequence of the HLA-B(∗)40:10 allele in Polynesians is a recombinant of HLA-B(∗)55:02 and -B(∗)40:01. HLA-B(∗)40:10 is in close association with HLA-C(∗)04:03, an allele identified as a hybrid of HLA-C(∗)04 and -C(∗)02. In this respect, our data resemble those reports on Amerindian tribes where inter-allele recombination has been a common means of generating diversity. However, we emphasize that Amerindian gene content per se is only a very minor element of the overall Polynesian genepool. The wider significance of HLA and MICA allele frequencies across the Pacific for modern day health is also discussed in terms of the frequency relative to reference populations of disease known to be associated with specific HLA and MICA markers. Thus, Polynesians and Maori are largely unaffected by "European autoimmune diseases" such as ankylosing spondylitis, uveitis and coeliacs disease, yet there are several Maori- and Polynesian-specific autoimmune diseases where the HLA and MICA associations are still to be determined.
(Copyright © 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)
المشرفين على المادة: 0 (HLA Antigens)
0 (Histocompatibility Antigens Class I)
0 (MHC class I-related chain A)
تواريخ الأحداث: Date Created: 20130625 Date Completed: 20140324 Latest Revision: 20211203
رمز التحديث: 20240628
DOI: 10.1016/j.humimm.2013.06.011
PMID: 23792058
قاعدة البيانات: MEDLINE
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