دورية أكاديمية
[The diagnostic and prognostic value of increase of blood pro-inflammatory and anti-inflammatory cytokines in chronic lymphatic leukemia].
| العنوان: | [The diagnostic and prognostic value of increase of blood pro-inflammatory and anti-inflammatory cytokines in chronic lymphatic leukemia]. |
|---|---|
| المؤلفون: | Zhevak TN, Chesnokova NP, Shelekhova TV |
| المصدر: | Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2013 Feb (2), pp. 33-6. |
| نوع المنشور: | English Abstract; Journal Article; Randomized Controlled Trial |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Meditsina Country of Publication: Russia (Federation) NLM ID: 9432021 Publication Model: Print Cited Medium: Print ISSN: 0869-2084 (Print) Linking ISSN: 08692084 NLM ISO Abbreviation: Klin Lab Diagn Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : "Meditsina", 1992- |
| مواضيع طبية MeSH: | Interleukin-4/*blood , Leukemia, Lymphocytic, Chronic, B-Cell/*blood , Leukemia, Lymphocytic, Chronic, B-Cell/*immunology , Tumor Necrosis Factor-alpha/*blood, Adult ; Aged ; Aged, 80 and over ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; Female ; Humans ; Immunoenzyme Techniques ; Interleukin-4/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Lymphoid Tissue/immunology ; Lymphoid Tissue/pathology ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Th2 Cells/immunology ; Th2 Cells/pathology ; Tomography, X-Ray Computed ; Tumor Necrosis Factor-alpha/immunology |
| مستخلص: | The article presents the results of study of cytokine profile of blood of patients with B-cell lymphatic leukemia. It is established that at diferent stages of disease the regular characteristic of changes in cytokine status is the increase of concentration of interleukin 4 (IL=4) and tumor necrosis factor This fact can be considered as one of leading pathogenic factors leading to disturbances of intercellular interaction in lymphoid tissue and to development of systemic metabolic and functional disorders. The parallelism between progressing increase of concentration of interleukin 4 and a-tumor necrosis factor character of qualitative and quantitative alterations of cell structure of peripheral blood, severity of clinical manifestations of disease are established. The indicators of concentration of interleukin 4 and a-tumor necrosis factor in blood are the objective diagnostic and prognostic criteria ofpathology development. They can complement the classification attributes of staging of the course of chronic lymphatic leukemia. |
| المشرفين على المادة: | 0 (Tumor Necrosis Factor-alpha) 207137-56-2 (Interleukin-4) |
| تواريخ الأحداث: | Date Created: 20130702 Date Completed: 20130725 Latest Revision: 20190816 |
| رمز التحديث: | 20240829 |
| PMID: | 23808008 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0869-2084 |
|---|