التفاصيل البيبلوغرافية
| العنوان: |
Simple clinical risk score identifies patients with serrated polyps in routine practice. |
| المؤلفون: |
Bouwens MW; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, the Netherlands., Winkens B, Rondagh EJ, Driessen AL, Riedl RG, Masclee AA, Sanduleanu S |
| المصدر: |
Cancer prevention research (Philadelphia, Pa.) [Cancer Prev Res (Phila)] 2013 Aug; Vol. 6 (8), pp. 855-63. Date of Electronic Publication: 2013 Jul 03. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101479409 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1940-6215 (Electronic) Linking ISSN: 19406215 NLM ISO Abbreviation: Cancer Prev Res (Phila) Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Philadelphia, PA : American Association for Cancer Research |
| مواضيع طبية MeSH: |
Colonoscopy* , Practice Patterns, Physicians'* , Quality Indicators, Health Care*, Colonic Polyps/*diagnosis , Colorectal Neoplasms/*diagnosis, Colonic Polyps/complications ; Colorectal Neoplasms/etiology ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Prognosis ; Prospective Studies ; Risk Factors ; Validation Studies as Topic |
| مستخلص: |
Large, proximal, or dysplastic (LPD) serrated polyps (SP) need accurate endoscopic recognition and removal as these might progress to colorectal cancer. Herewith, we examined the risk factors for having ≥1 LPD SP. We developed and validated a simple SP risk score as a potential tool for improving their detection. We reviewed clinical, endoscopic, and histologic features of serrated polyps in a study of patients undergoing elective colonoscopy (derivation cohort). A self-administered questionnaire was obtained. We conducted logistic regression analyses to identify independent risk factors for having ≥1 LPD SP and incorporated significant variables into a clinical score. We subsequently tested the performance of the SP score in a validation cohort. We examined 2,244 patients in the derivation and 2,402 patients in the validation cohort; 6.3% and 8.2% had ≥1 LPD SP, respectively. Independent risk factors for LPD SPs were age of more than 50 years [OR 2.2; 95% confidence interval (CI), 1.3-3.8; P = 0.004], personal history of serrated polyps (OR 2.6; 95% CI, 1.3-4.9; P = 0.005), current smoking (OR 2.2; 95% CI, 1.4-3.6; P = 0.001), and nondaily/no aspirin use (OR 1.8; 95% CI, 1.1-3.0; P = 0.016). In the validation cohort, a SP score ≥5 points was associated with a 3.0-fold increased odds for LPD SPs, compared with patients with a score <5 points. In the present study, age of more than 50 years, a personal history of serrated polyps, current smoking, and nondaily/no aspirin use were independent risk factors for having LPD SPs. The SP score might aid the endoscopist in the detection of such lesions. |
| تواريخ الأحداث: |
Date Created: 20130705 Date Completed: 20140304 Latest Revision: 20151119 |
| رمز التحديث: |
20240628 |
| DOI: |
10.1158/1940-6207.CAPR-13-0022 |
| PMID: |
23824513 |
| قاعدة البيانات: |
MEDLINE |
