دورية أكاديمية
أعرض في EDS

APOE genotype modulates proton magnetic resonance spectroscopy metabolites in the aging brain.

التفاصيل البيبلوغرافية
العنوان: APOE genotype modulates proton magnetic resonance spectroscopy metabolites in the aging brain.
المؤلفون: Gomar JJ; Litwin-Zucker Research Center, The Feinstein Institute for Medical Research, Manhasset, New York; FIDMAG Hermanas Hospitalarias, Sant Boi de Llobregat, Spain., Gordon ML; Litwin-Zucker Research Center, The Feinstein Institute for Medical Research, Manhasset, New York; Hofstra North Shore Long Island Jewish School of Medicine, Hempstead, New York., Dickinson D; National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland., Kingsley PB; Department of Radiology, North Shore University Hospital, Manhasset, New York., Uluğ AM; Hofstra North Shore Long Island Jewish School of Medicine, Hempstead, New York; Susan and Leonard Feinstein Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York., Keehlisen L; Litwin-Zucker Research Center, The Feinstein Institute for Medical Research, Manhasset, New York., Huet S; Litwin-Zucker Research Center, The Feinstein Institute for Medical Research, Manhasset, New York., Buthorn JJ; Litwin-Zucker Research Center, The Feinstein Institute for Medical Research, Manhasset, New York., Koppel J; Litwin-Zucker Research Center, The Feinstein Institute for Medical Research, Manhasset, New York; Hofstra North Shore Long Island Jewish School of Medicine, Hempstead, New York., Christen E; Litwin-Zucker Research Center, The Feinstein Institute for Medical Research, Manhasset, New York., Conejero-Goldberg C; Litwin-Zucker Research Center, The Feinstein Institute for Medical Research, Manhasset, New York., Davies P; Litwin-Zucker Research Center, The Feinstein Institute for Medical Research, Manhasset, New York; Hofstra North Shore Long Island Jewish School of Medicine, Hempstead, New York., Goldberg TE; Litwin-Zucker Research Center, The Feinstein Institute for Medical Research, Manhasset, New York; Hofstra North Shore Long Island Jewish School of Medicine, Hempstead, New York. Electronic address: tgoldber@nshs.edu.
المصدر: Biological psychiatry [Biol Psychiatry] 2014 May 01; Vol. 75 (9), pp. 686-92. Date of Electronic Publication: 2013 Jul 05.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2402 (Electronic) Linking ISSN: 00063223 NLM ISO Abbreviation: Biol Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Elsevier
Original Publication: New York, Plenum Pub. Corp.
مواضيع طبية MeSH: Aging/*genetics , Aging/*metabolism , Apolipoproteins E/*genetics , Brain/*metabolism, Aged ; Aged, 80 and over ; Apolipoprotein E3/genetics ; Apolipoprotein E4/genetics ; Choline/metabolism ; Creatine/metabolism ; Female ; Genotype ; Humans ; Inositol/metabolism ; Magnetic Resonance Spectroscopy/methods ; Male ; Mental Processes/physiology ; Middle Aged ; Neuropsychological Tests ; Protons
مستخلص: Background: Proton magnetic resonance spectroscopy ((1)H-MRS) studies on healthy aging have reported inconsistent findings and have not systematically taken into account the possible modulatory effect of APOE genotype. We aimed to quantify brain metabolite changes in healthy subjects in relation to age and the presence of the APOE E4 genetic risk factor for Alzheimer's disease. Additionally, we examined these measures in relation to cognition.
Methods: We studied a cohort of 112 normal adults between 50 and 86 years old who were genotyped for APOE genetic polymorphism. Measurements of (1)H-MRS metabolites were obtained in the posterior cingulate and precuneus region. Measures of general cognitive functioning, memory, executive function, semantic fluency, and speed of processing were also obtained.
Results: General linear model analysis demonstrated that older APOE E4 carriers had significantly higher choline/creatine and myo-inositol/creatine ratios than APOE E3 homozygotes. Structural equation modeling resulted in a model with an excellent goodness of fit and in which the APOE × age interaction and APOE status each had a significant effect on (1)H-MRS metabolites (choline/creatine and myo-inositol/creatine). Furthermore, the APOE × age variable modulation of cognition was mediated by (1)H-MRS metabolites.
Conclusions: In a healthy aging normal population, choline/creatine and myo-inositol/creatine ratios were significantly increased in APOE E4 carriers, suggesting the presence of neuroinflammatory processes and greater membrane turnover in older carriers. Structural equation modeling analysis confirmed these possible neurodegenerative markers and also indicated the mediator role of these metabolites on cognitive performance among older APOE E4 carriers.
(Copyright © 2014 Society of Biological Psychiatry. All rights reserved.)
التعليقات: Comment in: Biol Psychiatry. 2014 May 1;75(9):672-3. (PMID: 24731694)
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معلومات مُعتمدة: R01 AG038734 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: APOE genotype; Aging; cognitive function; neurodegeneration; proton magnetic resonance spectroscopy; structural equation modeling
المشرفين على المادة: 0 (Apolipoprotein E3)
0 (Apolipoprotein E4)
0 (Apolipoproteins E)
0 (Protons)
4L6452S749 (Inositol)
MU72812GK0 (Creatine)
N91BDP6H0X (Choline)
تواريخ الأحداث: Date Created: 20130709 Date Completed: 20141204 Latest Revision: 20211021
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC3887136
DOI: 10.1016/j.biopsych.2013.05.022
PMID: 23831342
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2402
DOI:10.1016/j.biopsych.2013.05.022