دورية أكاديمية
A purine nucleoside hydrolase from Trypanosoma gambiense, purification and properties.
| العنوان: | A purine nucleoside hydrolase from Trypanosoma gambiense, purification and properties. |
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| المؤلفون: | Schmidt G, Walter RD, Königk E |
| المصدر: | Tropenmedizin und Parasitologie [Tropenmed Parasitol] 1975 Mar; Vol. 26 (1), pp. 19-26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Georg Thieme Verlag Country of Publication: Germany NLM ID: 0423216 Publication Model: Print Cited Medium: Print ISSN: 0303-4208 (Print) Linking ISSN: 03034208 NLM ISO Abbreviation: Tropenmed Parasitol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Stuttgart : Georg Thieme Verlag |
| مواضيع طبية MeSH: | N-Glycosyl Hydrolases/*isolation & purification , Trypanosoma brucei gambiense/*enzymology, Adenine Phosphoribosyltransferase/isolation & purification ; Adenosine/metabolism ; Adenosine Kinase/isolation & purification ; Adenosine Monophosphate/biosynthesis ; Animals ; Cell-Free System ; Chromatography ; Chromatography, DEAE-Cellulose ; Guanosine ; Hydrogen-Ion Concentration ; Hypoxanthine Phosphoribosyltransferase/isolation & purification ; Inosine ; Isoelectric Focusing ; Ligases/isolation & purification ; N-Glycosyl Hydrolases/antagonists & inhibitors ; Oxidative Phosphorylation ; Purine Nucleosides ; Purine Nucleotides/biosynthesis ; Trypanosoma brucei gambiense/metabolism |
| مستخلص: | A purine nucleoside hydrolase from Trypanosoma gambiense was purified 160-fold. Preferred substrates of the reaction were adenosine, inosine and guanosine with a maximum of activity at pH 5.4. Competitive inhibitors of the adenosine hydrolysis were dimethylallyl adenosine, 6-methylmercaptopurine riboside, tubercidin, formycin B, 6-mercaptopurine riboside and deoxyadenosine. A metabolic scheme of adenosine nomophosphate salvage synthesis is discussed. |
| المشرفين على المادة: | 0 (Purine Nucleosides) 0 (Purine Nucleotides) 12133JR80S (Guanosine) 415SHH325A (Adenosine Monophosphate) 5A614L51CT (Inosine) EC 2.4.2.7 (Adenine Phosphoribosyltransferase) EC 2.4.2.8 (Hypoxanthine Phosphoribosyltransferase) EC 2.7.1.20 (Adenosine Kinase) EC 3.2.2.- (N-Glycosyl Hydrolases) EC 6.- (Ligases) K72T3FS567 (Adenosine) |
| تواريخ الأحداث: | Date Created: 19750301 Date Completed: 19750929 Latest Revision: 20131121 |
| رمز التحديث: | 20221208 |
| PMID: | 238316 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0303-4208 |
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