دورية أكاديمية
Interaction of some benzothiadiazine diuretics with beta-cyclodextrin.
| العنوان: | Interaction of some benzothiadiazine diuretics with beta-cyclodextrin. |
|---|---|
| المؤلفون: | Abdel-Rahman SI; Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Egypt., el-Sayed AM |
| المصدر: | Acta pharmaceutica Hungarica [Acta Pharm Hung] 1990 May; Vol. 60 (2-3), pp. 69-75. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Magyar Gyogyszereszeti Tarsasag Country of Publication: Hungary NLM ID: 0414322 Publication Model: Print Cited Medium: Print ISSN: 0001-6659 (Print) Linking ISSN: 00016659 NLM ISO Abbreviation: Acta Pharm Hung Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Budapest : Magyar Gyogyszereszeti Tarsasag Original Publication: Budapest. |
| مواضيع طبية MeSH: | Bendroflumethiazide* , Cyclodextrins* , Cyclopenthiazide* , Dextrins* , Hydroflumethiazide* , Sodium Chloride Symporter Inhibitors* , Starch* , beta-Cyclodextrins*, Diuretics ; Drug Stability ; Solubility |
| مستخلص: | The interaction of three structurally related benzothiadiazine diuretics, viz., hydroflumethiazide, bendrofluazide and cyclopenthiazide wit beta-cyclodextrin was investigated. The study aimed at enhancing the solubility of these poorly soluble drugs via inclusion complexation with beta-cyclodextrin, Solubility measurements revealed that complexes were formed between each of three drugs and beta-cyclodextrin, The complexes were found to have 1:1 stoichiometric ratios and stability constants of 165.4, 55.7 and 27.9 M-1 for cyclopenthiazide, bendrofluazide and hydroflumethiazide, respectively. UV spectrophotometric analysis of the formed complexes agreed with the solubility results. The variation in the extent of binding between each of the three drugs and beta-cyclodextrin was attributed to their variation in molecular volume, partition coefficient and electrostatic properties of the binding sites. |
| المشرفين على المادة: | 0 (Cyclodextrins) 0 (Dextrins) 0 (Diuretics) 0 (Sodium Chloride Symporter Inhibitors) 0 (beta-Cyclodextrins) 501CFL162R (Hydroflumethiazide) 5Q52X6ICJI (Bendroflumethiazide) 9005-25-8 (Starch) JV039JZZ3A (betadex) VX4S2N85F5 (Cyclopenthiazide) |
| تواريخ الأحداث: | Date Created: 19900501 Date Completed: 19900918 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| PMID: | 2386074 |
| قاعدة البيانات: | MEDLINE |
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