دورية أكاديمية
Ventricular response to dobutamine stress relates to the change in peak oxygen uptake during the 5-year follow-up in young patients with repaired tetralogy of Fallot.
| العنوان: | Ventricular response to dobutamine stress relates to the change in peak oxygen uptake during the 5-year follow-up in young patients with repaired tetralogy of Fallot. |
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| المؤلفون: | Luijnenburg SE; Department of Pediatrics, Division of Cardiology, Erasmus Medical Center-Sophia Children's Hospital, Sp-2426, PO Box 2060, Rotterdam 3000 CB, The Netherlands., Mekic S, van den Berg J, van der Geest RJ, Moelker A, Roos-Hesselink JW, Bogers AJ, de Rijke YB, Strengers JL, Mulder BJ, Vliegen HW, Helbing WA |
| المصدر: | European heart journal. Cardiovascular Imaging [Eur Heart J Cardiovasc Imaging] 2014 Feb; Vol. 15 (2), pp. 189-94. Date of Electronic Publication: 2013 Jul 18. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101573788 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-2412 (Electronic) Linking ISSN: 20472404 NLM ISO Abbreviation: Eur Heart J Cardiovasc Imaging Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Oxford University Press |
| مواضيع طبية MeSH: | Dobutamine* , Vasodilator Agents*, Oxygen Consumption/*physiology , Tetralogy of Fallot/*physiopathology , Ventricular Function, Right/*physiology, Adolescent ; Echocardiography, Stress/methods ; Electrocardiography ; Female ; Follow-Up Studies ; Humans ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Prospective Studies ; Tetralogy of Fallot/surgery ; Young Adult |
| مستخلص: | Aims: To evaluate the additional value of dobutamine stress testing in patients with repaired tetralogy of Fallot (TOF) by relating stress imaging parameters at baseline to relevant parameters of clinical condition and right ventricular (RV) size during a serial follow-up. Methods and Results: We prospectively included 27 patients (14 ± 4 years at baseline), who were studied twice with a 5-year interval. Patients underwent cardiovascular magnetic resonance imaging to assess RV systolic and diastolic function at rest and during dobutamine stress. Normal response to dobutamine was defined as a decrease in RV end-systolic volume, and a increase in RV ejection fraction (EF) during stress. Exercise testing and electrocardiography were performed to determine peak oxygen uptake (peak VO₂), QRS duration, and QT interval corrected for heart rate (QTc) interval. RV volumes, QRS duration, and QTc interval increased significantly from baseline to follow-up; peak VO₂ tended to decrease (95 ± 20-89 ± 14%, P = 0.086). Response to dobutamine was normal in 26 of 27 patients and remained stable during the follow-up [relative increase in RVEF during stress: +25 ± 9% (baseline) vs. +27 ± 10% (follow-up)]. A smaller relative increase in RVEF during stress at baseline related to a larger relative decrease in peak VO₂ during the follow-up (r = 0.59, P = 0.004). No significant associations were found with the relative increase in QRS duration, QTc interval, or RV end-diastolic volume during a 5-year follow-up. Conclusion: In a young TOF population, response to dobutamine stress was normal and remained stable during the 5-year follow-up. A smaller increase in RVEF during stress at baseline was predictive for a larger decrease in peak VO₂ during the 5-year follow-up. |
| فهرسة مساهمة: | Keywords: cardiovascular magnetic resonance imaging; dobutamine stress; exercise capacity; serial follow-up; tetralogy of Fallot |
| المشرفين على المادة: | 0 (Vasodilator Agents) 3S12J47372 (Dobutamine) |
| تواريخ الأحداث: | Date Created: 20130723 Date Completed: 20141013 Latest Revision: 20160511 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1093/ehjci/jet130 |
| PMID: | 23867136 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2047-2412 |
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| DOI: | 10.1093/ehjci/jet130 |