دورية أكاديمية
Roles of mitochondrial dynamics under stressful and normal conditions in yeast cells.
| العنوان: | Roles of mitochondrial dynamics under stressful and normal conditions in yeast cells. |
|---|---|
| المؤلفون: | Knorre DA; Belozersky Institute of Physico-Chemical Biology, Moscow State University, Vorobyevy Gory 1, Moscow 119992, Russia., Popadin KY, Sokolov SS, Severin FF |
| المصدر: | Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2013; Vol. 2013, pp. 139491. Date of Electronic Publication: 2013 Jul 14. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101479826 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0994 (Electronic) Linking ISSN: 19420994 NLM ISO Abbreviation: Oxid Med Cell Longev Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2011- : New York : Hindawi Pub. Corp. Original Publication: 2008-2010: Austin, TX : Landes Bioscience |
| مواضيع طبية MeSH: | Autophagy/*physiology , Mitochondrial Dynamics/*physiology , Saccharomyces cerevisiae/*metabolism, DNA, Mitochondrial/genetics ; Saccharomyces cerevisiae/physiology |
| مستخلص: | Eukaryotic cells contain dynamic mitochondrial filaments: they fuse and divide. Here we summarize data on the protein machinery driving mitochondrial dynamics in yeast and also discuss the factors that affect the fusion-fission balance. Fission is a general stress response of cells, and in the case of yeast this response appears to be prosurvival. At the same time, even under normal conditions yeast mitochondria undergo continuous cycles of fusion and fission. This seems to be a futile cycle and also expensive from the energy point of view. Why does it exist? Benefits might be the same as in the case of sexual reproduction. Indeed, mixing and separating of mitochondrial content allows mitochondrial DNA to segregate and recombine randomly, leading to high variation in the numbers of mutations per individual mitochondrion. This opens a possibility for effective purifying selection-elimination of mitochondria highly contaminated by deleterious mutations. The beneficial action presumes a mechanism for removal of defective mitochondria. We argue that selective mitochondrial autophagy or asymmetrical distribution of mitochondria during cell division could be at the core of such mechanism. |
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| المشرفين على المادة: | 0 (DNA, Mitochondrial) |
| تواريخ الأحداث: | Date Created: 20130820 Date Completed: 20140219 Latest Revision: 20211021 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC3728513 |
| DOI: | 10.1155/2013/139491 |
| PMID: | 23956814 |
| قاعدة البيانات: | MEDLINE |
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