دورية أكاديمية
أعرض في EDS

Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study.

التفاصيل البيبلوغرافية
العنوان: Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study.
المؤلفون: Luyckx V; Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium., Durant JF, Camboni A, Gilliaux S, Amorim CA, Van Langendonckt A, Irenge LM, Gala JL, Donnez J, Dolmans MM
المصدر: Journal of assisted reproduction and genetics [J Assist Reprod Genet] 2013 Oct; Vol. 30 (10), pp. 1289-99. Date of Electronic Publication: 2013 Aug 29.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 9206495 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7330 (Electronic) Linking ISSN: 10580468 NLM ISO Abbreviation: J Assist Reprod Genet Subsets: MEDLINE
أسماء مطبوعة: Publication: <2004- >: Amsterdam : Springer
Original Publication: New York : Plenum Press, c1992-
مواضيع طبية MeSH: Breast Neoplasms/*pathology , Fertility Preservation/*methods , Ovarian Follicle/*transplantation, Adolescent ; Adult ; Aged, 80 and over ; Animals ; Carrier Proteins/metabolism ; Cryopreservation ; Female ; Glycoproteins/metabolism ; Humans ; Mammaglobin B/biosynthesis ; Mammaglobin B/genetics ; Membrane Transport Proteins ; Mice ; Mice, SCID ; Pilot Projects ; Receptor, ErbB-2/metabolism ; Transplantation, Heterologous ; Young Adult
مستخلص: Purpose: To assess the safety of reimplantation of cryopreserved ovarian tissue from advanced-stage breast cancer patients.
Methods: Cryopreserved ovarian cortical fragments were obtained from 13 advanced-stage breast cancer patients aged 17-35 years. After thawing, part of the ovarian cortical tissue was grafted to severe combined immunodeficient mice for 6 months. The presence of malignant mammary cells in ovarian tissue was evaluated after thawing as well as after grafting by 1) histology and immunohistochemistry (epithelial membrane antigen, Her2/neu and gross cystic disease fluid protein 15 identification), and 2) detection of the MGB2 gene by qPCR.
Results: No malignant cells were evidenced by histology and immunohistochemistry. None of the mice died during the 6-month grafting period, nor developed macroscopically visible masses. MGB2 gene expression was detected by qPCR and confirmed by sequencing in frozen-thawed ovarian tissue in 4 cases and in grafts in 1 case.
Conclusions: This pilot study is the first to evaluate the risk of contamination of cryopreserved ovarian tissue from advanced-stage breast cancer patients by xenotransplantation for 6 months to immunodeficient mice, associated with more conventional screening methods. Our xenografting results are reassuring, but caution needs to be exercised, as MGB2 gene expression was detected in some cases. Larger numbers of ovarian tissue samples from patients with advanced-stage breast cancer are required to confirm our findings before ovarian tissue transplantation can be contemplated in these patients.
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المشرفين على المادة: 0 (Carrier Proteins)
0 (Glycoproteins)
0 (Mammaglobin B)
0 (Membrane Transport Proteins)
0 (PIP protein, human)
0 (SCGB2A1 protein, human)
EC 2.7.10.1 (ERBB2 protein, human)
EC 2.7.10.1 (Receptor, ErbB-2)
تواريخ الأحداث: Date Created: 20130831 Date Completed: 20140714 Latest Revision: 20211021
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3824859
DOI: 10.1007/s10815-013-0065-3
PMID: 23989997
قاعدة البيانات: MEDLINE
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